LEADER 05474nam 2200685 450 001 9910139399403321 005 20170810173627.0 010 $a0-470-66522-X 010 $a0-470-66519-X 035 $a(CKB)2480000000008344 035 $a(EBL)699355 035 $a(OCoLC)811498650 035 $a(SSID)ssj0000506247 035 $a(PQKBManifestationID)11303556 035 $a(PQKBTitleCode)TC0000506247 035 $a(PQKBWorkID)10513821 035 $a(PQKB)11714162 035 $a(MiAaPQ)EBC699355 035 $a(MiAaPQ)EBC7076180 035 $a(Au-PeEL)EBL7076180 035 $a(EXLCZ)992480000000008344 100 $a20160817h20112011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aDrug disposition and pharmacokinetics $efrom principles to applications /$fStephen H. Curry, Robin Whelpton 205 $a2nd ed. 210 1$aChichester, West Sussex, England :$cWiley-Blackwell,$d2011. 210 4$dİ2011 215 $a1 online resource (840 p.) 300 $aDescription based upon print version of record. 311 $a0-470-68446-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title; Copyright; Preface; About the Authors; 1: Chemical Introduction: Sources, Classification and Chemical Properties of Drugs; 1.1 Introduction; 1.2 Drug nomenclature and classification; 1.3 Properties of molecules; 1.4 Physicochemical interactions between drugs and other chemicals; 1.5 Law of mass action; 1.6 Ionization; 1.7 Partition coefficients; 1.8 Stereochemistry; Further reading and references; 2: Drug Administration and Distribution; 2.1 Introduction; 2.2 Drug transfer across biological membranes; 2.3 Drug administration; 2.4 Drug distribution; 2.5 Plasma protein binding 327 $a2.6 SummaryReferences and further reading; 3: Drug Elimination; 3.1 Introduction; 3.2 Metabolism; 3.3 Excretion; References and further reading; 4: Elementary Pharmacokinetics; 4.1 Introduction; 4.2 Single-compartment models; 4.3 Non-linear kinetics; 4.4 Relationship between dose, onset and duration of effect; 4.5 Limitations of single-compartment models; 4.6 Summary; References and further reading; 5: More Complex and Model Independent Pharmacokinetic Models; 5.1 Introduction; 5.2 Multiple compartment models; 5.3 Curve fitting and choice of most appropriate model 327 $a5.4 Model independent approaches5.5 Population pharmacokinetics; 5.6 Summary; References and further reading; 6: Kinetics of Metabolism and Excretion; 6.1 Introduction; 6.2 Metabolite kinetics; 6.3 Renal excretion; 6.4 Excretion in faeces; References and further reading; 7: Further Consideration of Clearance, and Physiological Modelling; 7.1 Introduction; 7.2 Clearance in vitro (metabolic stability); 7.3 Clearance in vivo; 7.4 Hepatic intrinsic clearance; 7.5 In vitro to in vivo extrapolation; 7.6 Limiting values of clearance; 7.7 Safe and effective use of clearance 327 $a7.8 Physiological modelling7.9 Inhomogeneity of plasma; References and further reading; 8: Drug Formulation: Bioavailability, Bioequivalence and Controlled-Release Preparations; 8.1 Introduction; 8.2 Dissolution; 8.3 Systemic availability; 8.4 Formulation factors affecting bioavailability; 8.5 Bioequivalence; 8.6 Controlled-release preparations; 8.7 Conclusions; References and further reading; 9: Factors Affecting Plasma Concentrations; 9.1 Introduction; 9.2 Time of administration of dose; 9.3 Food, diet and nutrition; 9.4 Smoking; 9.5 Circadian rhythms; 9.6 Weight and obesity; 9.7 Sex 327 $a9.8 Pregnancy9.9 Ambulation, posture and exercise; References and further reading; 10: Pharmacogenetics and Pharmacogenomics; 10.1 Introduction; 10.2 Methods for the study of pharmacogenetics; 10.3 N-acetyltransferase; 10.4 Plasma cholinesterase; 10.5 Cytochrome P450 polymorphisms; 10.6 Alcohol dehydrogenase and acetaldehyde dehydrogenase; 10.7 Thiopurine methyltransferase; 10.8 Phase 2 enzymes; 10.9 Transporters; 10.10 Pharmacodynamic differences; References and further reading; 11: Developmental Pharmacology and Age-related Phenomena; 11.1 Introduction 327 $a11.2 Scientific and regulatory environment in regard to younger and older patients 330 $aThis is an authoritative, comprehensive book on the fate of drug molecules in the body, including implications for pharmacological and clinical effects. The text provides a unique, balanced approach, examining the specific physical and biological factors affecting the absorption, distribution, metabolism and excretion of drugs, together with mathematical assessment of the concentrations in plasma and body fluids. Understanding the equations requires little more than a basic knowledge of algebra, laws of indices and logarithms, and very simple calculus. A companion web site contains additional 606 $aPharmacokinetics 606 $aBiopharmaceutics 606 $aDrugs$xMetabolism 608 $aElectronic books. 615 0$aPharmacokinetics. 615 0$aBiopharmaceutics. 615 0$aDrugs$xMetabolism. 676 $a615.7 676 $a615/.7 700 $aCurry$b Stephen H.$096094 702 $aWhelpton$b Robin 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139399403321 996 $aDrug disposition and pharmacokinetics$92074121 997 $aUNINA