LEADER 02827nam 2200649 a 450 001 9910139297803321 005 20230802012539.0 010 $a1-283-42514-9 010 $a9786613425140 010 $a1-118-18332-0 010 $a1-118-18333-9 010 $a1-118-18330-4 035 $a(CKB)2560000000079115 035 $a(EBL)817515 035 $a(OCoLC)772844539 035 $a(SSID)ssj0000589374 035 $a(PQKBManifestationID)11941216 035 $a(PQKBTitleCode)TC0000589374 035 $a(PQKBWorkID)10657269 035 $a(PQKB)11080739 035 $a(MiAaPQ)EBC817515 035 $a(Au-PeEL)EBL817515 035 $a(CaPaEBR)ebr10575441 035 $a(CaONFJC)MIL342514 035 $a(OCoLC)775437755 035 $a(EXLCZ)992560000000079115 100 $a20110809d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aClinical trial design$b[electronic resource] $eBayesian and frequentist adaptive methods /$fGuosheng Yin 210 $aHoboken, N.J. $cJohn Wiley & Sons$dc2012 215 $a1 online resource (366 p.) 225 1 $aWiley series in probability and statistics 300 $aDescription based upon print version of record. 311 $a0-470-58171-9 320 $aIncludes bibliographical references and indexes. 327 $aFundamentals of clinical trials -- Frequentist versus Bayesian statistics -- Phase I trial design -- Phase II trial design -- Phase III trial design -- Adaptive randomization -- Late onset toxicity -- Drug combination trials -- Targeted therapy design. 330 $aA balanced treatment of the theories, methodologies, and design issues involved in clinical trials using statistical methods There has been enormous interest and development in Bayesian adaptive designs, especially for early phases of clinical trials. However, for phase III trials, frequentist methods still play a dominant role through controlling type I and type II errors in the hypothesis testing framework. From practical perspectives, Clinical Trial Design: Bayesian and Frequentist Adaptive Methods provides comprehensive coverage of both Bayesian and frequentist approaches to a 410 0$aWiley series in probability and statistics. 606 $aClinical trials$xStatistical methods 606 $aBayesian statistical decision theory 606 $aMathematical statistics 615 0$aClinical trials$xStatistical methods. 615 0$aBayesian statistical decision theory. 615 0$aMathematical statistics. 676 $a610.72/4 700 $aYin$b Guosheng$0857693 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139297803321 996 $aClinical trial design$91915096 997 $aUNINA