LEADER 03044nam 2200565 a 450 001 9910139235403321 005 20240313151452.0 010 $a1-118-49808-9 010 $a1-299-24238-3 010 $a1-118-49817-8 035 $a(CKB)2560000000098550 035 $a(EBL)1129726 035 $a(OCoLC)825108262 035 $a(SSID)ssj0000831870 035 $a(PQKBManifestationID)11482945 035 $a(PQKBTitleCode)TC0000831870 035 $a(PQKBWorkID)10881229 035 $a(PQKB)10967504 035 $a(MiAaPQ)EBC1129726 035 $a(Au-PeEL)EBL1129726 035 $a(CaPaEBR)ebr10662562 035 $a(CaONFJC)MIL455488 035 $a(PPN)182857441 035 $a(EXLCZ)992560000000098550 100 $a20130123d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aChemical synthesis of nucleoside analogues /$fedited by Pedro Merino 205 $a1st ed. 210 $aHoboken, N.J. $cWiley$dc2013 215 $a1 online resource (918 p.) 300 $aDescription based upon print version of record. 311 $a1-118-00751-4 320 $aIncludes bibliographical references and index. 327 $aDeoxynucleoside analogues / Vicente Gotor -- Nucleosides modified at the base moiety / Luigi Agrofoglio -- Acyclic nucleosides / Antonin Holy -- Phosphorylated nucleoside analogues / Giovanni Romeo -- Triphosphorylated nucleoside analogues / Chris Meier -- Pro-nucleotides / Christian Perigaud -- C-nucleoside / Sergio Castillo?n -- Isonucleosides / Vasu Nair -- Conformationally constrained nucleosides / Jacques Lebreton -- Spironucleosides / Maria Jose Camarasa -- L-nucleosides / Daniela Perrone -- Carbocyclic nucleosides / Eric Leclerc -- Uncommon three-, four, and six-membered nucleosides / Elisabetta Groaz -- Thionucleosides / L.S. Jeong -- Azanucleosides and related compounds / Tomas Tejero -- Oxathiolane and dioxolane nucleosides / Annalisa Guaragna -- Isoxazolidinyl nucleosides / Ugo Chiacchio -- Nucleoside antibiotics / Apurba Dutta -- Building blocks for peptide nucleic acids / Pedro Merino. 330 $aCompiles current tested and proven approaches to synthesize novel nucleoside analogues Featuring contributions from leading synthetic chemists from around the world, this book brings together and describes tested and proven approaches for the chemical synthesis of common families of nucleoside analogues. Readers will learn to create new nucleoside analogues with desired therapeutic properties by using a variety of methods to chemically modify natural nucleosides, including:Changes to the heterocyclic baseModification of substituents at the sugar ring