LEADER 05297nam 2200673Ia 450 001 9910139192103321 005 20170810191416.0 010 $a1-118-03512-7 010 $a1-282-68335-7 010 $a9786612683350 010 $a0-470-62272-5 010 $a0-470-62271-7 035 $a(CKB)2560000000011999 035 $a(EBL)543002 035 $a(OCoLC)645098676 035 $a(SSID)ssj0000413479 035 $a(PQKBManifestationID)11299772 035 $a(PQKBTitleCode)TC0000413479 035 $a(PQKBWorkID)10381118 035 $a(PQKB)11221945 035 $a(PQKBManifestationID)16524544 035 $a(PQKB)23042129 035 $a(MiAaPQ)EBC543002 035 $a(DLC) 2016299616 035 $a(EXLCZ)992560000000011999 100 $a20091203d2010 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aCancer risk assessment$b[electronic resource] $echemical carcinogenesis, hazard evaluation, and risk quantification /$fedited by Ching-Hung Hsu, Todd Stedeford 210 $aHoboken, N.J. $cWiley$dc2010 215 $a1 online resource (858 p.) 300 $aDescription based upon print version of record. 311 $a0-470-23822-4 320 $aIncludes bibliographical references and index. 327 $aCANCER RISK ASSESSMENT: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification; CONTENTS; PREFACE; CONTRIBUTORS; ABBREVIATIONS AND ACRONYMS; PART I: CANCER RISK ASSESSMENT, SCIENCE POLICY, AND REGULATORY FRAMEWORKS; CHAPTER 1: CANCER RISK ASSESSMENT; CHAPTER 2: SCIENCE POLICY AND CANCER RISK ASSESSMENT; CHAPTER 3: HAZARD AND RISK ASSESSMENT OF CHEMICAL CARCINOGENICITY WITHIN A REGULATORY CONTEXT; CHAPTER 4: USE OF CANCER RISK ASSESSMENTS IN DETERMINATION OF REGULATORY STANDARDS; PART II: CANCER BIOLOGY AND TOXICOLOGY; CHAPTER 5: THE INTERPLAY OF CANCER AND BIOLOGY 327 $aCHAPTER 6: CHEMICAL CARCINOGENESIS: A BRIEF HISTORY OF ITS CONCEPTS WITH A FOCUS ON POLYCYCLIC AROMATIC HYDROCARBONSCHAPTER 7: HORMESIS AND CANCER RISKS: ISSUES AND RESOLUTION; CHAPTER 8: THRESHOLDS FOR GENOTOXIC CARCINOGENS: EVIDENCE FROM MECHANISM-BASED CARCINOGENICITY STUDIES; PART III: GENETIC TOXICOLOGY, TESTING GUIDELINES AND REGULATIONS, AND NOVEL ASSAYS; CHAPTER 9: DEVELOPMENT OF GENETIC TOXICOLOGY TESTING AND ITS INCORPORATION INTO REGULATORY HEALTH EFFECTS TEST REQUIREMENTS; CHAPTER 10: GENETIC TOXICOLOGY TESTING GUIDELINES AND REGULATIONS; CHAPTER 11: IN VITRO GENOTOX ASSAYS 327 $aCHAPTER 12: IN VIVO GENOTOXICITY ASSAYSPART IV: ASSESSING THE HUMAN RELEVANCE OF CHEMICAL-INDUCED TUMORS; CHAPTER 13: FRAMEWORK ANALYSIS FOR DETERMINING MODE OF ACTION AND HUMAN RELEVANCE; CHAPTER 14: EXPERIMENTAL ANIMAL STUDIES AND CARCINOGENICITY; CHAPTER 15: CANCER EPIDEMIOLOGY; CHAPTER 16: RODENT HEPATOCARCINOGENESIS; CHAPTER 17: MODE OF ACTION ANALYSIS AND HUMAN RELEVANCE OF LIVER TUMORS INDUCED BY PPAR a ACTIVATION; CHAPTER 18: ALPHA 2U-GLOBULIN NEPHROPATHY AND CHRONIC PROGRESSIVE NEPHROPATHY AS MODES OF ACTION FOR RENAL TUBULE TUMOR INDUCTION IN RATS, AND THEIR POSSIBLE INTERACTION 327 $aCHAPTER 19: URINARY TRACT CALCULI AND BLADDER TUMORSPART V: METHODS FOR INFORMING CANCER RISK QUANTIFICATION; CHAPTER 20: (Q) SAR ANALYSIS OF GENOTOXIC AND NONGENOTOXIC CARCINOGENS: A STATE-OF-THE-ART OVERVIEW; CHAPTER 21: PHYSIOLOGICALLY BASED PHARMACOKINETIC (PBPK) MODELS IN CANCER RISK ASSESSMENT; CHAPTER 22: GENOMICS AND ITS ROLE IN CANCER RISK ASSESSMENT; CHAPTER 23: COMPUTATIONAL TOXICOLOGY IN CANCER RISK ASSESSMENT; PART VI: GENERAL APPROACHES FOR QUANTIFYING CANCER RISKS; CHAPTER 24: LINEAR LOW-DOSE EXTRAPOLATIONS 327 $aCHAPTER 25: QUANTITATIVE CANCER RISK ASSESSMENT OF NONGENOTOXIC CARCINOGENSCHAPTER 26: NONLINEAR LOW-DOSE EXTRAPOLATIONS; CHAPTER 27: CANCER RISK ASSESSMENT: MORE UNCERTAIN THAN WE THOUGHT; CHAPTER 28: COMBINING NEOPLASMS FOR EVALUATION OF RODENT CARCINOGENESIS STUDIES; CHAPTER 29: CANCER RISK BASED ON AN INDIVIDUAL TUMOR TYPE OR SUMMING OF TUMORS; CHAPTER 30: EXPOSURE RECONSTRUCTION AND CANCER RISK ESTIMATE DERIVATION; INDEX 330 $a"With a weight-of-the-evidence approach, cancer risk assessment indentifies hazards, determines dose-response relationships, and assesses exposure to characterize the true risk. This book focuses on the quantitative methods for conducting chemical cancer risk assessments for solvents, metals, mixtures, and nanoparticles. It links these to the basic toxicology and biology of cancer, along with the impacts on regulatory guidelines and standards. By providing insightful perspective, Cancer Risk Assessment helps researchers develop a discriminate eye when it comes to interpreting data accurately and separating relevant information from erroneous"--Provided by publisher. 606 $aCarcinogens 606 $aHealth risk assessment 608 $aElectronic books. 615 0$aCarcinogens. 615 0$aHealth risk assessment. 676 $a616.99/4071 676 $a616.994071 701 $aHsu$b Ching-Hung$0874014 701 $aStedeford$b Todd$0874015 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139192103321 996 $aCancer risk assessment$91951486 997 $aUNINA LEADER 00916nam0 2200301 450 001 9910401859503321 005 20220915123053.0 010 $a978-88-921-3201-6 100 $a20200630d2019---- 0km y ba ba 101 0 $aita 102 $aIT 105 $ay 001yy 200 1 $aSostenibilità$eprofili giuridici, economici e manageriali delle PMI italiane$fa cura di Fabiola Massa$gprefazione di Enrico Giovannini 210 $aTorino$cGiappichelli$dc2019 215 $aXIV, 200 p.$d24 cm 676 $a658.4060945$v23$zita 702 1$aMassa,$bFabiola 702 1$aGiovannini,$bEnrico$f<1957- > 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910401859503321 952 $aAZEGI472A$b2811$fDECBC 952 $aVIII H 870$b2022/200$fFGBC 952 $aVIII H 876$b2021/290$fFGBC 959 $aFGBC 959 $aDECBC 996 $aSostenibilità$91533144 997 $aUNINA