LEADER 03490nam 2200661 450 001 9910139129203321 005 20200520144314.0 010 $a1-118-40654-0 010 $a1-118-40655-9 010 $a1-118-40653-2 035 $a(CKB)2550000001273030 035 $a(EBL)1674212 035 $a(SSID)ssj0001181667 035 $a(PQKBManifestationID)11665633 035 $a(PQKBTitleCode)TC0001181667 035 $a(PQKBWorkID)11146827 035 $a(PQKB)11783272 035 $a(OCoLC)880451431 035 $a(MiAaPQ)EBC1674212 035 $a(DLC) 2013051181 035 $a(Au-PeEL)EBL1674212 035 $a(CaPaEBR)ebr10862677 035 $a(CaONFJC)MIL595157 035 $a(OCoLC)867001317 035 $a(EXLCZ)992550000001273030 100 $a20140502h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNeuroinflammation and CNS disorders /$fedited by Nicola Woodroofe, Sandra Amor 205 $aFirst edition. 210 1$aWest Sussex, England :$cJohn Wiley & Sons,$d2014. 210 4$dİ2014 215 $a1 online resource (420 p.) 300 $aDescription based upon print version of record. 311 $a1-118-40641-9 311 $a1-306-63906-9 320 $aIncludes bibliographical references and index. 327 $aImmune privilege of the brain -- Innate immunity in the CNS : a focus on the myeloid cell -- Adaptive immune responses in the CNS -- Ageing and the immune response in the CNS -- Brain repair : the role of endogenous and transplanted neural stem cells -- Neuroinflammation in Alzheimer's, Parkinson's, and Huntington's diseases -- CNS infections -- Neuroimmunology of amyotrophic lateral sclerosis -- Demyelinating disorders of the CNS -- Other autoimmune disorders : systemic lupus erythematosus, primary Sjogren's syndrome, gluten-related neurological dysfunction, and paraneoplastic neurological syndromes -- Inflammation in the pathogenesis of depression -- Immune responses in the CNS in epilepsy -- Inflammatory mediators and dysfunction of the neurovascular unit following ischaemia reperfusion -- Spinal cord injury -- Immune responses to tumours in the CNS. 330 $a The last decade has seen an upsurge of information on the role of immune responses in neurodegenerative disorders. In many of these diseases it is still unclear whether the innate and adaptive responses are pathogenic or play a role in repair, and thus understanding their precise roles is key to controlling these diseases by designing immune-therapeutic approaches. The connection between many neurological diseases is the realisation that the immune and nervous systems are inextricable linked, and that perturbations in this delicate balance are involved in many disorders. This has open 606 $aInflammation$xPathophysiology 606 $aCentral nervous system$xDiseases$xImmunological aspects 606 $aNervous system$xDegeneration$xImmunological aspects 615 0$aInflammation$xPathophysiology. 615 0$aCentral nervous system$xDiseases$xImmunological aspects. 615 0$aNervous system$xDegeneration$xImmunological aspects. 676 $a616.80479 702 $aWoodroofe$b Nicola 702 $aAmor$b Sandra 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139129203321 996 $aNeuroinflammation and CNS disorders$92189333 997 $aUNINA