LEADER 04713nam 2200637 a 450 001 9910139054303321 005 20200520144314.0 010 $a1-118-35587-3 010 $a1-118-35588-1 010 $a1-118-35586-5 035 $a(CKB)2560000000102387 035 $a(EBL)1211621 035 $a(OCoLC)836557859 035 $a(SSID)ssj0000889611 035 $a(PQKBManifestationID)11478765 035 $a(PQKBTitleCode)TC0000889611 035 $a(PQKBWorkID)10876774 035 $a(PQKB)10140008 035 $a(MiAaPQ)EBC1211621 035 $a(DLC) 2013014142 035 $a(Au-PeEL)EBL1211621 035 $a(CaPaEBR)ebr10718830 035 $a(CaONFJC)MIL497769 035 $a(PPN)178632937 035 $a(EXLCZ)992560000000102387 100 $a20150303d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aMolecular basis of oxidative stress$b[electronic resource] $echemistry, mechanisms, and disease pathogenesis /$fedited by Frederick A. Villamena 210 $aHoboken, N.J. $cWiley$dc2013 215 $a1 online resource (448 p.) 300 $aDescription based upon print version of record. 311 $a0-470-57218-3 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title page; Copyright page; Contents; Preface; About the Contributors; Contributors; 1: Chemistry of Reactive Species; 1.1 Redox Chemistry; 1.2 Classification of Reactive Species; 1.2.1 Type of Orbitals; 1.2.2 Stability of Radicals; 1.2.3 ROS; 1.2.4 Reactive Nitrogen Species; 1.2.5 Reactive Sulfur and Chlorine Species; 1.3 Reactivity; 1.3.1 Thermodynamic Considerations; 1.3.2 Kinetic Considerations; 1.4 Origins of Reactive Species; 1.4.1 Biological Sources; 1.4.2 Nonbiochemical Sources; 1.5 Methods of Detection; 1.5.1 In Vitro; 1.5.2 In Vivo; References 327 $a2: Lipid Peroxidation and NitrationOverview; 2.1 Peroxidation of PUFAs; 2.1.1 Hydroperoxy Fatty Acid Isomers (HpETEs and HpODEs); 2.1.2 Hydroxy Fatty Acids (HETEs and HODEs); 2.1.3 Isoleukotrienes; 2.1.4 Epoxy Alcohols; 2.2 Cyclic Endoperoxides and Their Products; 2.2.1 Isoprostanes; 2.2.2 Diepoxide Pathway Products; 2.2.3 Serial Cyclic Endoperoxides; 2.3 Fragmented Products of Lipid Peroxidation; 2.3.1 Short-Chain Alkanes, Aldehydes, and Acids; 2.3.2 Oxidatively Fragmented Phospholipids; 2.3.3 PAF Acetylhydrolase; 2.3.4 Hydroxyalkenals; 2.3.5 Malondialdehyde; 2.3.6 Acrolein 327 $a2.4 Epoxy Fatty Acids2.5 Lipid Nitrosylation; 2.5.1 Formation of Reactive Nitrogen Species; 2.5.2 Lipid Nitration Reactions; 2.5.3 Detection of Lipid Nitration In Vivo; 2.5.4 Bioactivities of Nitrated Lipids; Summary; References; 3: Protein Posttranslational Modification; Overview; 3.1 Oxidative Stress-Related PTMs: Oxidation Reactions; 3.1.1 Cysteine; 3.1.2 Methionine; 3.1.3 Oxidation of Aromatic Amino Acids; 3.1.4 Oxidation of Aliphatic Amino Acids; 3.2 Amino Acid Modification by Oxidation-Produced Electrophiles; 3.2.1 Electrophiles Formed by Oxidative Stress 327 $a4.3.3 Novel Types of Ribose and Guanine Oxidative Lesions and Future OutlookFuture Outlook of DNA Oxidative Lesions; References; 5: Downregulation of Antioxidants and Phase 2 Proteins; Overview; 5.1 Definitions of Antioxidants and Phase 2 Proteins; 5.1.1 Antioxidants; 5.1.2 Phase 2 Proteins; 5.2 Roles in Oxidative Stress; 5.2.1 Superoxide Dismutase; 5.2.2 Catalase; 5.2.3 GSH and GSH-Related Enzymes; 5.2.4 NAD(P)H:Quinone Oxidoreductase; 5.2.5 Heme Oxygenase; 5.2.6 Ferritin; 5.2.7 UDP-Glucuronosyltransferase; 5.3 Molecular Regulation; 5.3.1 General Consideration; 5.3.2 Nrf2 Signaling 327 $a5.3.3 Other Regulators 330 $a Sets the stage for the development of better diagnostic techniques and therapeutics Featuring contributions from an international team of leading clinicians and biomedical researchers, Molecular Basis of Oxidative Stress reviews the molecular and chemical bases of oxidative stress, describing how oxidative stress can lead to the development of cancer and cardiovascular and neurodegenerative diseases. Moreover, it explains the potential role of free radicals in both the diagnosis and the development of therapeutics to treat disease. Molecular Basis of Oxidative Stres 606 $aOxidative stress 606 $aOxidation 615 0$aOxidative stress. 615 0$aOxidation. 676 $a571.9/453 701 $aVillamena$b Frederick A$0886084 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139054303321 996 $aMolecular basis of oxidative stress$91978681 997 $aUNINA