LEADER 05512nam 2200697 450 001 9910139031003321 005 20200520144314.0 010 $a1-118-74274-5 010 $a1-118-74292-3 010 $a1-118-74317-2 035 $a(CKB)2550000001159883 035 $a(EBL)1547074 035 $a(OCoLC)863040891 035 $a(SSID)ssj0001047626 035 $a(PQKBManifestationID)11656637 035 $a(PQKBTitleCode)TC0001047626 035 $a(PQKBWorkID)11159545 035 $a(PQKB)11587617 035 $a(OCoLC)874967825 035 $a(MiAaPQ)EBC1547074 035 $a(DLC) 2013036793 035 $a(Au-PeEL)EBL1547074 035 $a(CaPaEBR)ebr10798087 035 $a(CaONFJC)MIL543088 035 $a(PPN)185879616 035 $a(EXLCZ)992550000001159883 100 $a20130911h20142014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPlant chemical biology /$fedited by Dominique Audenaert, Paul Overvoorde 210 1$aHoboken, New Jersey :$cWiley,$d[2014] 210 4$dİ2014 215 $a1 online resource (321 p.) 300 $aDescription based upon print version of record. 311 $a0-470-94669-5 311 $a1-306-11837-9 320 $aIncludes bibliographical references and index. 327 $aPlant Chemical Biology; Copyright; Contents; Preface; Contributors; Part One Introduction; 1.1 From Herbal Remedies to Cutting-Edge Science: A Historical Perspective of Plant Chemical Biology; 1.1.1 Herbal Remedies and Pharmacology in the Ancient World; 1.1.2 Alchemy, Chemistry, and the Isolation of the Bioactive Metabolites; 1.1.3 The Discovery of Phytohormones and the Foundation of Modern Plant Chemical Biology; 1.1.4 The Dawn of Plant Synthetic Chemistry; 1.1.5 Serendipity Versus Rational Design of Chemical Libraries; 1.1.6 The Development of Combinatorial Chemistry 327 $a1.1.7 Plant Chemical Biology in the -Omics Era1.1.8 Introduction of Bioinformatics and Cheminformatics; 1.1.9 Unique Challenges in the Field of Chemical Genomic Research; 1.1.10 Concluding Remarks; Acknowledgments; References; Part Two Sources of Small Molecules; 2.1 Compound Collections; 2.1.1 Introduction; 2.1.2 Commercial Sources; 2.1.3 Companies Providing Nonproprietary, Nonparallel Synthesized Libraries Sourced Externally to the Company; 2.1.4 Companies Providing In-House Designed, Parallel Synthesized Libraries; 2.1.5 Results of Database Analysis 327 $a2.1.6 Compound Selection and Database Filtering2.1.7 Substructure Similarity/Dissimilarity; 2.1.8 Cluster Analysis; 2.1.9 Pharmacophore Analysis; 2.1.10 Compound Acquisition Format and Storage; Acknowledgments; References; 2.2 Combinatorial Chemistry Library Design; 2.2.1 Introduction; 2.2.2 Bioavailability; 2.2.3 Chemical Space; 2.2.4 Privileged Structures; 2.2.5 Fragment-Based Design; 2.2.6 Ligand-Based Design; 2.2.7 Structure-Based Design; 2.2.8 Conclusion and Summary; References; 2.3 Natural Product-Based Libraries; 2.3.1 Introduction; 2.3.2 Plant-Based Collections 327 $a2.3.3 Microbial-Derived Samples2.3.4 Samples of Marine Origin; 2.3.5 Future Perspectives; 2.3.6 Concluding Remarks; References; Part Three Identification of New Chemical Tools by High-Throughput Screening; 3.1 Assay Design for High-Throughput Screening; 3.1.1 Introduction; 3.1.2 Approaching Assay Development; 3.1.3 Assay Development; 3.1.4 Assay Types and Considerations; 3.1.5 Automation Adaptation and Validation; 3.1.6 Closing; Acknowledgment; References; Part Four Use of Chemical Biology to study Plant Physiology 327 $a4.1 Use of Chemical Biology to Understand Auxin Metabolism, Signaling, and Polar Transport4.1.1 Introduction; 4.1.2 Naturally Occurring Auxins; 4.1.3 Auxin Biosynthesis; 4.1.4 Auxin Conjugation and Release by Hydrolysis; 4.1.5 Synthetic Auxins; 4.1.6 Polar Auxin Transport; 4.1.7 Current Models of Auxin Signaling; 4.1.8 Application of Auxin-Related Molecules in Chemical Genetic Approach; 4.1.9 Chemical Probes on Auxin Signaling from Chemical Library and Natural Sources; 4.1.10 Rational Design of Auxin Antagonist on the Basis of TIR1 Structure 327 $a4.1.11 Chemical Probes on Auxin Transport from Chemical Library and Natural Sources 330 $a"The application of plant chemical biology is currently limited to specialized subfields of plant research. By examining how chemical biology can be applied to study plant biology, Plant Chemical Biology illustrates how chemical biology is a means to identify small molecules that can be used to identify the targets of currently used herbicides, as well as to develop new herbicides or plant growth regulators. The author introduces researchers and graduate students to the chemical biology toolbox required to perform successful chemical biology studies. The text also examines several chemical biology studies to show how they allowed novel insights into the field of plant physiology and plant cellular processes"--Provided by publisher. 606 $aBotanical chemistry 606 $aPlants$xEffect of chemicals on 615 0$aBotanical chemistry. 615 0$aPlants$xEffect of chemicals on. 676 $a572/.2 701 $aAudenaert$b Dominique$f1976-$0946686 701 $aOvervoorde$b Paul$f1968-$0946687 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910139031003321 996 $aPlant chemical biology$92138893 997 $aUNINA