LEADER 02215nam 2200445Ia 450 001 996389103303316 005 20210104172039.0 035 $a(CKB)4940000000096648 035 $a(EEBO)2264210300 035 $a(OCoLC)ocn879331359e 035 $a(OCoLC)879331359 035 $a(EXLCZ)994940000000096648 100 $a20140507d1700 uy 0 101 0 $aeng 135 $aurbn||||a|bb| 200 12$aA new and easy method to understand the Roman history, with an exact chronology of the reigns of the emperors$b[electronic resource] $ean account of the most eminent authors, when they flourish'd : and an abridgment of the Roman antiquities and customs : by way of dialogue, for the use of the Duke of Burgundy /$fdone out of French, with very large additions and ammendments, by Mr. Tho. Brown ; to which is added two chapters ; one of the customes, another of the Roman money ; and also a collection of phrases out of the Roman antiquities, in English and Latin ; with a complete index to the whole 205 $aThe second edition; with some additions. 210 $aDublin $cRe-printed at the back of Dick's Coffee-House, for John Foster, bookseller, at the sign of the Dolphin in Skinner-Row$d1700 215 $a[12], 344+ p. $ctables 300 $aTranslation of the author's Me?thode pour apprendre facilement l'histoire romaine. 300 $aMs. notes. 300 $aInitials. 300 $aImperfect: tightly bound, with slight loss of text. 300 $aReproduction of original in: National Library of Ireland. 330 $aeebo-0095 606 $aEmperors$zRome$vEarly works to 1800 607 $aRome$xAntiquities$vEarly works to 1800 607 $aRome$xCustoms and practices$vEarly works to 1800 607 $aRome$xHistory$vEarly works to 1800 608 $aQuestions and answers.$2rbgenr 615 0$aEmperors 700 $aFourcroy$cAbbe? de.$01006640 702 $aBrown$b Thomas$f1663-1704, 702 $aFoster$b John 801 0$bUMI 801 1$bUMI 906 $aBOOK 912 $a996389103303316 996 $aA new and easy method to understand the Roman history, with an exact chronology of the reigns of the emperors$92316991 997 $aUNISA LEADER 05738nam 2200709Ia 450 001 9910139008603321 005 20200520144314.0 010 $a1-118-61073-3 010 $a1-118-61074-1 010 $a1-299-46528-5 010 $a1-118-61075-X 035 $a(CKB)2550000001019426 035 $a(EBL)1166922 035 $a(OCoLC)850209522 035 $a(SSID)ssj0000855714 035 $a(PQKBManifestationID)11440512 035 $a(PQKBTitleCode)TC0000855714 035 $a(PQKBWorkID)10804846 035 $a(PQKB)10701429 035 $a(MiAaPQ)EBC1166922 035 $a(DLC) 2013014058 035 $a(Au-PeEL)EBL1166922 035 $a(CaPaEBR)ebr10687823 035 $a(CaONFJC)MIL477778 035 $a(PPN)178710350 035 $a(EXLCZ)992550000001019426 100 $a20130330d2013 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aAdvanced delivery and therapeutic applications of RNAi$b[electronic resource] /$fedited by Kun Cheng, Ram I. Mahato 205 $a2nd ed. 210 $aChichester, West Sussex $cJohn Wiley & Sons Inc.$d2013 215 $a1 online resource (535 p.) 300 $aDescription based upon print version of record. 311 $a1-119-97686-3 320 $aIncludes bibliographical references and index. 327 $aAdvanced Delivery and Therapeutic Applications of RNAi; Contents; Preface; Contributors; About the Editors; Part 1: Introduction and Basics of RNAi; 1 Mechanisms and Barriers to RNAi Delivery; 1.1 Introduction; 1.2 Barriers to Systemic RNAi Delivery; 1.3 Rational Design to Improve RNAi Efficacy; 1.4 Chemical Modifications to Enhance siRNA Stability and Reduce Immune Response; 1.5 Cellular Uptake and Intracellular Release of siRNA; 1.6 Combinatorial Targeting for Targeted RNAi Delivery; 1.7 Cell-Specific Aptamer-Functionalized Nanocarriers for RNAi Delivery 327 $a1.8 The Clinical Development and Challenges of siRNAs Therapeutics1.9 Conclusion and Perspectives; References; 2 Analysis of siRNA Delivery Using Various Methodologies; 2.1 Introduction; 2.2 Checkpoints for Analyzing siRNA Delivery; 2.2.1 Circulation Checkpoint; 2.2.2 Organ or Tissue Checkpoint; 2.2.3 Cellular Checkpoint; 2.2.4 RISC Checkpoint; 2.2.5 Target mRNA Knockdown (Indirect Checkpoint); 2.2.6 Protein and Outcome (Indirect Checkpoint); 2.2.7 Safety (Indirect Checkpoint); 2.3 Methods for Analysis of siRNA; 2.3.1 General Considerations; 2.3.2 Hybridization-Based (Non-Imaging) Methods 327 $a2.3.3 Non-Hybridization-Based (Non-Imaging) Methods2.3.4 Imaging-Based (Non-Hybridization) Methods; 2.3.5 Imaging-Based (Hybridization) Methods; 2.4 Case Study for siRNA Delivery Analysis; References; 3 Challenges and Opportunities in Bringing RNAi Technologies from Bench to Bed; 3.1 Introduction; 3.2 RNAi Mediator (siRNA or shRNA); 3.2.1 siRNA; 3.2.2 Vector-derived shRNA; 3.2.3 miRNAs; 3.3 Safety Issues of RNAi Mediators; 3.3.1 Immune Stimulation; 3.3.2 RNAi Overexpression; 3.4 Efficacy of RNAi Mediators; 3.4.1 Therapeutic Response; 3.5 RNAi Mediators in Clinical Trials; 3.6 Conclusion 327 $aReferences4 Nonclinical Safety Assessments and Clinical Pharmacokinetics for Oligonucleotide Therapeutics: A Regulatory Perspective; 4.1 Introduction; 4.2 Unique Properties of Oligonucleotide-based Therapeutics; 4.3 Regulation of Oligonucleotide-Based Therapeutics; 4.3.1 Submission to the FDA; 4.3.2 Review Process for Non-clinical Studies; 4.3.3 Regulatory Issues; 4.3.4 Clinical Pharmacokinetics; 4.4 Conclusion; Disclaimer; Appendix; References; 5 Role of Promoters and MicroRNA Backbone for Efficient Gene Silencing; 5.1 Introduction; 5.2 Promoters for shRNA Expression 327 $a5.2.1 Constitutive Promoters5.2.2 Inducible Promoters; 5.2.3 Site Specific Promoters; 5.3 miRNA-based shRNAs; 5.3.1 miRNA-based shRNA Enhances Gene Silencing; 5.3.2 miRNA-based shRNA Reduces Toxicities; 5.3.3 Application of miRNA-based shRNA for Combination Gene Therapy; 5.4 Concluding Remarks; References; Part 2: RNAi Delivery Strategies; 6 Bioconjugation of siRNA for Site-specific Delivery; 6.1 Introduction; 6.2 Conjugation Strategy; 6.2.1 RNA Chemical Modification; 6.2.2 Site of Conjugation; 6.2.3 Conjugation Chemistry; 6.3 Bioconjugates for Site-specific Delivery 327 $a6.3.1 Antibody-siRNA Bioconjugates 330 $a"Commonly used by researchers to develop technologies for modifying and studying genetic process, RNA interference (RNAi) has many potential uses in medicine, biotechnology, and functional genomics. 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