LEADER 05087nam 2200625 450 001 9910138996803321 005 20200520144314.0 010 $a1-118-70929-2 010 $a1-118-70931-4 010 $a1-118-70933-0 035 $a(CKB)2550000001130089 035 $a(EBL)1469187 035 $a(OCoLC)860923523 035 $a(OCoLC)853618740 035 $a(MiAaPQ)EBC1469187 035 $a(DLC) 2013029041 035 $a(Au-PeEL)EBL1469187 035 $a(CaPaEBR)ebr10777216 035 $a(CaONFJC)MIL530136 035 $a(PPN)224484710 035 $a(EXLCZ)992550000001130089 100 $a20130722d2014 uy| 0 101 0 $aeng 135 $aur|n|---||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aAlkynes in cycloadditions /$fauthor, Irina A. Maretina ; translated from the Russian by Boris I. Ionin ; consulting editor, John C. Tebby 210 1$aChichester, West Sussex :$cJohn Wiley & Sons, Inc.,$d2014. 215 $a1 online resource (312 p.) 300 $aIncludes index. 311 $a1-118-61532-8 311 $a1-299-98885-7 327 $aAlkynes in Cycloadditions; Contents; Preface; Acknowledgments; Biography; 1 Introduction; 2 Regioselective Syntheses of Polysubstituted Benzenes Catalyzed by Transition Metal Complexes; 2.1 [2+2+2] Cycloaddition Reactions of Acetylenes; 2.1.1 Reactions of Alkynes with Metallocyclopentadiene as an Intermediate; 2.1.2 Intra-intermolecular [2+2+2] Cycloaddition of Alkynes; 2.2 Stereochemical Aspect of Intramolecular and Intermolecular Reactions of Diynes with Monoalkynes; 2.2.1 Strategy of Enantioselective [2+2+2] Cycloaddition; 2.3 Heteroatom Bound to the Triple Bond 327 $a2.3.1 Nitrogen-Containing Substrates2.3.2 [2+2+2] Cycloadditions of Alkynes to Nitriles: Synthesis of Pyridines; 2.4 Heterohelicens. Asymmetric Syntheses; 2.4.1 Oxygen-Containing Helicens; 2.4.2 Nitrogen-Containing Helicens. Helical Dications; 2.5 Aromatic Rings with Boron and Silicon Substituents; 2.6 [2+2+2] Cycloaddition Reactions of 1-Alkynylphosphines and Their Derivatives; 2.7 Intramolecular [2+2+2] Cycloaddition of Diynes to Alkenes; 2.7.1 Allene as an Alkene Component; 2.7.2 Formation of Polycyclic Cyclohexadienes by Ru-catalyzed Cascade Reactions of 1,6-Diynes and Alkenes 327 $a2.7.3 Stereochemical Aspects of the Reaction of Diynes with Alkenes2.7.4 Hetero-[2+2+2] Cycloaddition of Alkynes to Compounds with a Multiple Carbon-Heteroatom Bond; 2.8 Reactions of [4+2] Cycloaddition and Other Approaches to the Synthesis of Polysubstituted Benzenes; 2.8.1 Reactions of Conjugated Enynes; 2.8.2 Acceleration of Pd-catalyzed [4+2]-Benzannulation in the Reaction of Enynes and Diynes in the Presence of Lewis Acids and Bronsted Bases; 2.9 Combined Reactions 327 $a2.9.1 Formal [4+2+2] Cycloaddition of 1,6-Diynes to 1,3-Dienes Catalyzed by Ru: Formation of Cyclooctatrienes and Vinylcyclohexadienes2.9.2 Formation of Eight-Membered Ring Systems by [4+2+2] Annulation; 2.9.3 AuBr3 (AlCl3)- and Cu(OTf)2-Catalyzed [4+2] Cycloaddition of Alkynyl- and Alkenyl-Enynones and Enynals: An Approach to Functionalized Polycyclic Hydrocarbons; 2.10 Construction of Polycyclic Systems; 2.10.1 Strategies for the Synthesis of Steroid Systems by Co-catalyzed [2+2+2] Cycloaddition of Nonconjugated Enyne-Allenes and Enediynes 327 $a2.10.2 Cobalt(I)-Mediated [2+2+2] Cyclization of Allene-Diynes: A Diastereoselective Approach to 11-aryl Steroid Core. 11-Aryl-Substituted Steroid Systems by Co-catalyzed [2+2+2] Cyclization of Allene-Diynes2.10.3 Synthesis of (3S)-hydroxyandrosta-5,7-diene-17-ones via Intramolecular Cobalt-Mediated [2+2+2] Cycloaddition; 2.10.4 Intramolecular Cycloaddition of Nonconjugated Enediynes of a Higher Order as a Route to Functionalized Condensed Polycyclic Systems; 2.10.5 A Strategy for the Synthesis of Aromatic Molecular-Bowl Hydrocarbons 327 $a2.10.6 A Route to Archimedenes: Total Synthesis of C3h-symmetric [7]phenylenes 330 $a Acetylene systems present a new route to cyclic compounds as an alternative to more traditional methods employed in classical organic chemistry. The synthesis of cyclic structures based on acetylene systems has important applications in the formation of nanostructures, naturally occurring compounds and chemosensory materials for the design of nonlinear optics, electronic and photonic devices. Alkynes in Cycloadditions presents a modern review of regioselective synthesis of aromatic and non-aromatic carbocyclic and heterocyclic ring systems based primarily on [2+2+2] and [4+2] c 606 $aAlkynes 606 $aRing formation (Chemistry) 615 0$aAlkynes. 615 0$aRing formation (Chemistry) 676 $a547/.413 700 $aMaretina$b Irina A$0978583 701 $aTebby$b John C.$f1933-$099393 701 $aIonin$b B. I$0978584 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910138996803321 996 $aAlkynes in cycloadditions$92230449 997 $aUNINA LEADER 01135nam a22002891i 4500 001 991000356559707536 005 20031213181601.0 008 040204s1993 it |||||||||||||||||ita 035 $ab12604264-39ule_inst 035 $aARCHE-061147$9ExL 040 $aDip. SSC$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 082 04$a791.43 100 1 $aPoppi, Roberto$0144278 245 10$aDizionario del cinema italiano /$cRoberto Poppi ; con la collaborazione di Enrico Lancia 260 $aRoma :$bGremese,$c1993 300 $av. ;$c24 cm 440 0$aDizionari Gremese 505 $aComprende: I$tregisti : dal 1930 ai giorni nostri. - 276 p., [16] c. di tav. : ill. ; 25 cm. - ISBN 8876057250 650 4$aCinema$zItalia$xEnciclopedie e dizionari 650 4$aRegisti$zItalia 700 1 $aLancia, Enrico 907 $a.b12604264$b22-01-21$c12-02-04 912 $a991000356559707536 945 $aLE021 C33E4C$g1$iLE021-10607$lle021$o-$pE0.00$q-$rl$so $t0$u0$v0$w0$x0$y.i13085591$z12-02-04 996 $aDizionario del cinema italiano$9278733 997 $aUNISALENTO 998 $ale021$b12-02-04$cm$da $e-$fita$git $h0$i1 LEADER 04517nam 22005535 450 001 9910616362303321 005 20251009102856.0 010 $a9783031092220 010 $a3-031-09222-8 024 7 $a10.1007/978-3-031-09222-0 035 $a(MiAaPQ)EBC7107414 035 $a(Au-PeEL)EBL7107414 035 $a(CKB)24995984800041 035 $a(PPN)265861810 035 $a(DE-He213)978-3-031-09222-0 035 $a(OCoLC)1347019344 035 $a(EXLCZ)9924995984800041 100 $a20221005d2022 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDermal Absorption and Decontamination $eA Comprehensive Guide /$fedited by Aileen M. Feschuk, Rebecca M. Law, Howard I. Maibach 205 $a1st ed. 2022. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2022. 215 $a1 online resource (339 pages) 225 1 $aMedicine Series 311 08$aPrint version: Feschuk, Aileen M. Dermal Absorption and Decontamination Cham : Springer International Publishing AG,c2022 9783031092213 320 $aIncludes bibliographical references and index. 327 $aSkin Decontamination with Water: Evidence from In Vivo Human Studies -- Towards a harmonized protocol for in vitro human skin decontamination efficacy -- In Vitro Human Skin Decontamination with Water: Chemical Warfare Agents or Simulants -- In Vitro Human Skin Decontamination with Water: Occupational Contaminants -- Skin Decontamination with Water: Evidence from In Vivo Animal Models -- Skin Decontamination with Water: Evidence from In Vitro Animal Models -- Dry Decontamination with Readily Available Products -- A Review of Reactive Skin Decontamination Lotion Efficacy -- Aqueous suspensions of Fuller?s earth potentiate the adsorption capacities of Paraoxon and improve skin decontamination properties -- Development of a next generation military skin decontaminant: Initial efficacy studies of Zirconium Hydroxide -- Findings from the PHOENIX project: ?Protocols for Hair and the Optimisation of Existing and Novel decontamination Interventions through experimentation -- Twenty clinically pertinent factors/ observations for percutaneous absorption in humans -- Lateral Spread and Percutaneous Penetration: An Overview -- Regional Variation in Percutaneous Absorption: Evidence from In Vitro Human Models -- Experimental Variability in TEWL Data -- Relationships Between Skin of Color and the TEWL Barrier . 330 $aThis book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a ?wash-in effect? (an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date. Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists. 410 0$aMedicine Series 606 $aDermatology 606 $aDermatology 615 0$aDermatology. 615 14$aDermatology. 676 $a733 676 $a616.5 702 $aFeschuk$b Aileen M. 702 $aLaw$b Rebecca M. 702 $aMaibach$b Howard I. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910616362303321 996 $aDermal absorption and decontamination$93044769 997 $aUNINA