LEADER 05418nam 2200709 450 001 9910138994403321 005 20230803220313.0 010 $a1-118-74918-9 010 $a1-118-74901-4 010 $a1-118-74932-4 035 $a(CKB)2550000001138457 035 $a(EBL)1498559 035 $a(OCoLC)861559725 035 $a(SSID)ssj0001041366 035 $a(PQKBManifestationID)11580812 035 $a(PQKBTitleCode)TC0001041366 035 $a(PQKBWorkID)11043713 035 $a(PQKB)10144454 035 $a(OCoLC)868973445 035 $a(MiAaPQ)EBC1498559 035 $a(Au-PeEL)EBL1498559 035 $a(CaPaEBR)ebr10788036 035 $a(CaONFJC)MIL538158 035 $a(OCoLC)870563869 035 $a(EXLCZ)992550000001138457 100 $a20131112d2014 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aRecurrent pregnancy loss /$fedited by Ole B. Christiansen ; cover designed by Sarah Dickinson 210 1$aChichester, England :$cWiley-Blackwell,$d2014. 210 4$dİ2014 215 $a1 online resource (210 p.) 225 0 $aGynecology in practice 300 $aDescription based upon print version of record. 311 $a0-470-67294-3 311 $a1-306-06907-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aRecurrent Pregnancy Loss; Copyright; Contents; Series Foreword; Contributors; Preface to the First Edition; 1 Obtaining the Relevant History; Introduction; Demographic data; Parental Age; BMI; Lifestyle Factors; Social Class; Occupational Factors; Partner; Reproductive history; Clinical Appearance of Pregnancy Losses; Gestational Age of Pregnancy Losses; Perinatal Data; Disease history; Family history; Conclusions; Bibliography; 2 Which Investigations Are Relevant?; Introduction; Thrombophilia tests; Tests; Coagulation Cascade, Regulatory Mechanisms; Inherited Thrombophilia 327 $aPrevalence of Inherited ThrombophiliaPathophysiological Mechanisms Leading to Pregnancy Loss; Strength of the Association; Anticoagulant Therapy; Evidence and Drawbacks; Screening for thrombophilia in women with recurrent miscarriage; Conclusions; Parental and fetal karyotyping; Parental Chromosome Abnormalities; Parental Chromosome Abnormalities and Recurrent Miscarriage; Testing; Reproductive consequences of carrier status; Treatment or prevention; Fetal karyotype; Testing the Fetal Karyotype; Prognostic Value and Treatment; Conclusions; Tests for diagnosing uterine anomalies 327 $aCongenital Uterine AnomaliesUterine Anomalies and Pregnancy Outcomes; Diagnosis of uterine anomalies; Prognosis of pregnancy outcome; Treatment of Uterine Anomalies; Conclusion; Thyroid function tests; Thyroid Disorders; Diagnosis of Thyroid Disorders; Thyroid Autoimmunity and Pregnancy Outcomes; Treatment of Thyroid Autoimmunity; Screening for Thyroid Autoimmunity; Further Research on Thyroid Autoimmunity; Conclusions; Summary; Bibliography; 3 NK Cells in Peripheral Blood and the Endometrium; Introduction; NK cells and reproduction; Methods of assessment 327 $aNK cell analysis in recurrent miscarriageNK cell testing in practice; Targeted immune therapy; Immune therapy caution; When to offer NK cell testing; Bibliography; 4 Cytokines and Cytokine Gene Polymorphisms in Recurrent Pregnancy Loss; Introduction - Cytokines and pregnancy: basic concepts; Interactions between Treg cells, Th17 cells, and cytokines and normal pregnancy and RPL; Cytokine gene polymorphisms and RPL - an overview; Practical evaluation of cytokines for the diagnostic of RPL; Conclusion; Bibliography; 5 How to Assess the Prognosis after Recurrent Miscarriage; Introduction 327 $aMethod of studySpecific causes of RPL and prognosis; Number of Miscarriages; Maternal Age; Karyotype of Previous Miscarriage; Concurrent Infertility; Late Pregnancy Losses; Primary, Secondary, or Tertiary Aborter Status; Parental Chromosomal Rearrangements; Antiphospholipid Antibodies; Hereditary Thrombophilias; Immunological Factors; Thyroid Dysfunction; Uterine Anomalies; Sperm Defects; Psychological Stress; Prognosis in pregnancy; Classification of prognosis; Good Prognosis; Medium Prognosis Patients; Poor Prognosis Patients; Conclusions; Bibliography 327 $a6 Which Treatments Should be Offered? PGD/PGS, Allogeneic Lymphocyte Immunization, Intravenous Immunoglobulin 330 $a Recurrent pregnancy loss is an emotional challenge for patients. This book offers a practical approach to office-based gynecologists and trainee gynecologists to learn how to identify the root causes and minimize the risks of further miscarriage in subsequent pregnancies. This book is part of the Gynecology in Practice Series, which aims to provide a clinical 'in the office' or 'at the bedside' guide to effective patient care for gynecologists. 410 0$aGIP - Gynaecology in Practice 606 $aMiscarriage 606 $aMiscarriage$xPrevention 615 0$aMiscarriage. 615 0$aMiscarriage$xPrevention. 676 $a618.392 701 $aDickinson$b Sarah$0939483 701 $aChristiansen$b Ole B$0965044 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910138994403321 996 $aRecurrent pregnancy loss$92189476 997 $aUNINA