LEADER 05410nam 2200685 450 001 9910138994303321 005 20230803220329.0 010 $a1-118-69787-1 010 $a1-118-69543-7 010 $a1-118-69590-9 035 $a(CKB)2550000001138458 035 $a(EBL)1498521 035 $a(OCoLC)861559718 035 $a(SSID)ssj0001039361 035 $a(PQKBManifestationID)11572638 035 $a(PQKBTitleCode)TC0001039361 035 $a(PQKBWorkID)10986694 035 $a(PQKB)10550077 035 $a(MiAaPQ)EBC1498521 035 $a(Au-PeEL)EBL1498521 035 $a(CaPaEBR)ebr10788062 035 $a(CaONFJC)MIL538159 035 $a(EXLCZ)992550000001138458 100 $a20131109d2014 uy 0 101 0 $aeng 135 $aur|nu---uuuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aHypoglycaemia in clinical diabetes /$fedited by Brian M. Frier, Simon R. Heller, Rory J. McCrimmon ; cover design by Steve Thompson 205 $aThird edition. 210 1$aChichester, England ;$aHoboken, New Jersey :$cWiley-Blackwell,$d2014. 215 $a1 online resource (xi, 380 pages) $cillustrations 300 $aDescription based upon print version of record. 311 $a0-470-67200-5 311 $a1-306-06908-4 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aCover; Title page; Copyright page; Contents; List of Contributors; Preface; 1: Normal Glucose Metabolism and Responses to Hypoglycaemia; Normal Glucose Homeostasis; Fasting (Figure 1.1a); Fed state (Figure 1.1b); Effects of Glucose Deprivation on Central Nervous System Metabolism; Counterregulation During Hypoglycaemia; Hormonal Changes During Hypoglycaemia; Activation of the autonomic nervous system; Neuroendocrine activation (Box 1.3); Physiological Responses; Haemodynamic changes (Box 1.4); Changes in regional blood flow (Box 1.5 and Figure 1.6); Functional changes (Box 1.6); Conclusions 327 $aAcknowledgementReferences; 2: Symptoms of Hypoglycaemia and Effects on Mental Performance and Emotions; Introduction; Symptoms of Hypoglycaemia; Identifying the symptoms; The validity of symptom beliefs; Classifying symptoms of hypoglycaemia; Symptoms in children and older people; From symptom perception to action; Symptom generation; Symptom detection; Low blood glucose detection - symptom interpretation; Symptom scoring systems; Acute Hypoglycaemia and Cognitive Functioning; Influences on the degree of, and threshold for, cognitive dysfunction 327 $aAre the cognitive changes during acute hypoglycaemia important and valid?Acute Hypoglycaemia and Emotions; Conclusions; References; 3: Counterregulatory Deficiencies in Diabetes; Introduction; Normal Glucose Counterregulation; Age and Glucose Counterregulation; Defective Hormonal Glucose Counterregulation; Insulin; Glucagon; Catecholamines; Cortisol and growth hormone; Mechanisms of Counterregulatory Failure; Systemic mediator; Brain fuel transport; Brain metabolism; Hypoglycaemia tolerance; Conclusions; References; 4: Frequency, Causes and Risk Factors for Hypoglycaemia in Type 1 Diabetes 327 $aIntroductionDefinitions of Hypoglycaemia; Biochemical definitions of hypoglycaemia; Clinical definitions of hypoglycaemia; Frequency of Hypoglycaemia; Frequency of mild, symptomatic hypoglycaemia; Causes of Hypoglycaemia; Patient error; Alcohol; Exercise; Risk Factors for Severe Hypoglycaemia; Intensive insulin therapy; Strict glycaemic control; Genetic predisposition to hypoglycaemia; Absent endogenous insulin secretion; Dose and type of insulin; Sleep; Microvascular complications; Social and psychological factors; Endocrinopathies; Other risk factors 327 $aCauses and risk factors for hypoglycaemia: summary and conclusionsConclusions; References; 5: Nocturnal Hypoglycaemia; Introduction; Epidemiology - How Common is Nocturnal Hypoglycaemia?; Causes of Nocturnal Hypoglycaemia; The limitations of therapeutic insulin delivery; Impaired counterregulatory responses to hypoglycaemia during nocturnal hypoglycaemia; Supine posture; Sleep; Consequences of Nocturnal Hypoglycaemia; Impaired awareness of hypoglycaemia; The 'dead in bed' syndrome; Neurological consequences of nocturnal hypoglycaemia on cerebral function 327 $aCan Nocturnal Hypoglycaemia be Predicted? 330 $aHypoglycaemia in Clinical Diabetes, 3rd Edition Edited by: Brian M Frier, Royal Infirmary of Edinburgh, Edinburgh, UK Simon R Heller, University of Sheffield, Sheffield, UK Rory J McCrimmon, University of Dundee, Dundee, UK If you regularly see patients with diabetes who experience hypoglycaemia and need expert guidance, then this is the book for you. Hypoglycaemia in Clinical Diabetes, 3rd Edition once again provides health professionals involved in the management of people with 606 $aInsulin 606 $aHypoglycemia 615 0$aInsulin. 615 0$aHypoglycemia. 676 $a616.466 701 $aFrier$b Brian M$0963357 701 $aHeller$b Simon$0963358 701 $aMcCrimmon$b Rory J$0963359 701 $aThompson$b Steve$0279479 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910138994303321 996 $aHypoglycaemia in clinical diabetes$92184278 997 $aUNINA