LEADER 02418nam 2200577 a 450 001 9910138868603321 005 20200520144314.0 010 $a3-527-64564-0 010 $a1-283-89324-X 010 $a3-527-64566-7 035 $a(CKB)2550000000109402 035 $a(EBL)1120902 035 $a(OCoLC)805654697 035 $a(SSID)ssj0000738117 035 $a(PQKBManifestationID)12334535 035 $a(PQKBTitleCode)TC0000738117 035 $a(PQKBWorkID)10788950 035 $a(PQKB)11614529 035 $a(MiAaPQ)EBC1120902 035 $a(Au-PeEL)EBL1120902 035 $a(CaPaEBR)ebr10580287 035 $a(CaONFJC)MIL420574 035 $a(PPN)178875252 035 $a(EXLCZ)992550000000109402 100 $a20120730d2012 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aLead optimization for medicinal chemists$b[electronic resource] $epharmacokinetic properties of functional groups and organic compounds /$fFlorencio Zaragoza Do?rwald 210 $aWeinheim, Germany $cWiley-VCH$d2012 215 $a1 online resource (623 p.) 300 $aDescription based upon print version of record. 311 $a3-527-33226-X 320 $aIncludes bibliographical references and index. 327 $apt. 1. Introduction -- pt. 2. The pharmacokinetic properties of compound classes. 330 $aSmall structural modifications can significantly affect the pharmacokinetic properties of drug candidates. This book, written by a medicinal chemist for medicinal chemists, is a comprehensive guide to the pharmacokinetic impact of functional groups, the pharmacokinetic optimization of drug leads, and an exhaustive collection of pharmacokinetic data, arranged according to the structure of the drug, not its target or indication. The historical origins of most drug classes and general aspects of modern drug discovery and development are also discussed. The index contains all the drug names and sy 606 $aPharmacokinetics 606 $aDrug development 615 0$aPharmacokinetics. 615 0$aDrug development. 676 $a615.19 700 $aDo?rwald$b Florencio Zaragoza$0875082 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910138868603321 996 $aLead optimization for medicinal chemists$91953499 997 $aUNINA