LEADER 02627nam 2200433 450 001 9910138292203321 005 20230719200446.0 010 $a953-51-6617-4 035 $a(CKB)3230000000075341 035 $a(NjHacI)993230000000075341 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/65386 035 $a(EXLCZ)993230000000075341 100 $a20221014d2011 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aAcute Leukemia $eThe Scientist's Perspective and Challenge /$fedited by Mariastefania Antica 210 $cIntechOpen$d2011 210 1$aRijeka :$cInTech,$d2011. 210 4$dİ2011 215 $a1 online resource (xi, 442 pages) $cillustrations 311 $a953-307-553-8 320 $aIncludes bibliographical references. 330 $aThis book provides a comprehensive overview of he basic mechanisms underlying areas of acute leukemia, current advances, and future directions in management of this disease. The first section discusses the classification of acute leukemia, taking into account diagnoses dependent on techniques that are essential, and thankfully readily available, in the laboratory. The second section concerns recent advances in molecular biology, markers, receptors, and signaling molecules responsible for disease progression, diagnostics based on biochips and other molecular genetic analysis. These advances provide clinicians with important understanding and improved decision making towards the most suitable therapy for acute leukemia. Biochemical, structural, and genetic studies may bring a new era of epigenetic based drugs along with additional molecular targets that will form the basis for novel treatment strategies. Later in the book, pediatric acute leukemia is covered, emphasizing that children are not small adults when it comes to drug development. The last section is a collection of chapters about treatment, as chemotherapy-induced toxicity is still a significant clinical concern. The present challenge lies in reducing the frequency and seriousness of adverse effects while maintaining efficacy and avoiding over-treatment of patients. 517 $aAcute leukemia 606 $aAcute leukemia 610 $aOncology 615 0$aAcute leukemia. 676 $a616.99419 700 $aAntica$b Mariastefania$4edt$01372056 702 $aAntica$b Mariastefania 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910138292203321 996 $aAcute Leukemia$93401919 997 $aUNINA LEADER 01118nas 2200409-a 450 001 996216560803316 005 20231101153458.0 011 $a1420-9128 035 $a(OCoLC)60623121 035 $a(CKB)954925395411 035 $a(CONSER)--2007233937 035 $a(DE-599)ZDB2379946-8 035 $a(EXLCZ)99954925395411 100 $a20050614b18882006 s-- - 101 0 $ager 135 $aurun||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEclogae geologicae Helvetiae 210 $aBasel $cBirkha?user 300 $aRefereed/Peer-reviewed 311 $a0012-9402 606 $aGeology$vPeriodicals 606 $aGeology$zSwitzerland$vPeriodicals 606 $aGeology$2fast$3(OCoLC)fst00940627 607 $aSwitzerland$2fast 608 $aPeriodicals.$2fast 615 0$aGeology 615 0$aGeology 615 7$aGeology. 676 $a554.94 712 02$aSchweizerische Geologische Gesellschaft. 906 $aJOURNAL 912 $a996216560803316 996 $aEclogae geologicae Helvetiae$9103480 997 $aUNISA