LEADER 02079oam 2200385z 450 001 9910137749303321 005 20240606204201.0 010 $a9789535166221 010 $a9535166220 035 $a(CKB)3230000000076480 035 $a(Perlego)2011224 035 $a(oapen)doab65402 035 $a(EXLCZ)993230000000076480 100 $a20150504d2012uuuu -u 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdamedia 182 $cc$2rdamedia 183 $ao$2rdacarrier 200 00$aMuscle Biopsy /$fedited by Challa Sundaram 210 $cInTech 215 $a1 online resource 311 08$a9789533077789 311 08$a9533077786 330 $a"Investigation of muscle diseases has changed dramatically with the understanding of genetic basis of a wide range of muscle diseases. Muscle biopsy has become a powerful tool not only to provide diagnosis but to make tissue available for genetic studies and to basic scientists for biomedical research. Accurate interpretation of muscle biopsy to detect cell dysfunction/ damage/death or absence / abnormality of a protein or genetic defect by the sophisticated technologies is important to guide treatment of various muscle diseases. In this book on muscle biopsy various chapters deal with the procedure and interpretation of muscle biopsy, its use in the culture of myotubes and membrane transport studies.Muscle biopsy is an important technique to investigate mitochondrial dysfunction and the mitochondrial DNA integrity in oxidation. Phosphorylation in various metabolic diseases like obesity, type 2 diabetes mellitus and peripheral vascular disease is explored in the other chapters with detailed descriptions on methodology. This book provides the advances in the basic techniques of muscle biopsy for a neuroscientist." 606 $aBiopsy 606 $aMuscles 610 $aHistopathology 615 2$aBiopsy. 615 2$aMuscles. 700 $aSundaram$b Challa$0909602 906 $aBOOK 912 $a9910137749303321 996 $aMuscle Biopsy$92035378 997 $aUNINA