LEADER 05267nam 2200661Ia 450 001 9910137562803321 005 20200520144314.0 010 $a1-283-28268-2 010 $a9786613282682 010 $a1-118-07558-7 010 $a1-118-07556-0 010 $a1-118-07560-9 035 $a(CKB)3190000000022605 035 $a(EBL)697907 035 $a(OCoLC)828303964 035 $a(SSID)ssj0000554358 035 $a(PQKBManifestationID)11330147 035 $a(PQKBTitleCode)TC0000554358 035 $a(PQKBWorkID)10516988 035 $a(PQKB)10053740 035 $a(MiAaPQ)EBC697907 035 $a(Au-PeEL)EBL697907 035 $a(CaPaEBR)ebr10577575 035 $a(CaONFJC)MIL328268 035 $a(PPN)223980129 035 $a(EXLCZ)993190000000022605 100 $a20110118d2011 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAntibiotics and antibiotic resistance$b[electronic resource] /$fOla Skl?d 210 $aHoboken, NJ $cWiley$dc2011 215 $a1 online resource (223 p.) 300 $aTranslation of: Antibiotika och antibiotikaresistens / Olga Skl?d. c2006. 300 $aIncludes index. 311 $a0-470-43850-9 327 $aANTIBIOTICS AND ANTIBIOTIC RESISTANCE; CONTENTS; Preface; 1 ANTIBIOTICS: THE GREATEST TRIUMPH OF SCIENTIFIC MEDICINE; Selectivity; Development of Resistance; Sulfonamide: The First Antibacterial Agent Acting Selectively; Chemotherapeutics and Antibiotics; Penicillin: The First Antibiotic; The First Therapeutic Trial; Rediscovery of Penicillin by a Basic Scientific Approach; Betalactams; Streptomycin: The Second Antibiotic in the History of Antibacterial Agents; The First Remedy for Tuberculosis; Conclusion; 2 DISTRIBUTION OF ANTIBIOTICS; Quantitative Evaluation of Antibiotics Consumption 327 $aDefined Daily DosesInternational Distribution of Antibiotics: A Scandinavian Example; Control of Antibiotics Overuse; 3 SULFONAMIDES AND TRIMETHOPRIM; General Aspects Regarding the Development of Resistance; Sulfonamides; Sulfonamides as Remedies; Resistance to Sulfonamide; Resistance to Sulfonamides in Neisseria meningitidis; Characterization of the Sulfonamide-Resistant Dihydropteroate Synthase in N. meningitidis; Characterization of the Other Sulfonamide-Resistant Dihydropteroate Synthase in N. meningitidis; Resistance to Sulfonamides in Streptococcus pyogenes 327 $aResistance to Sulfonamides in Campylobacter jejuniResistance to Sulfonamides in Streptococcus pneumoniae; Resistance to Sulfonamides in Pneumocystis jiroveci (carinii); Resistance to Sulfonamides in Staphylococcus aureus and S. haemolyticus; Resistance to Sulfonamides in Mycobacterium leprae; Plasmid-Borne Resistance to Sulfonamides; Trimethoprim; Innate Resistance to Trimethoprim; Chromosomal Resistance to Trimethoprim; Plasmid-Borne Resistance to Trimethoprim; Possible Pathogenicity Change in C. jejuni by Acquiring Trimethoprim Resistance Genes 327 $aExperimental Test of the Reversibility of Trimethoprim ResistanceConclusion; 4 PENICILLINS AND OTHER BETALACTAMS; The Betalactam Ring: The Characteristic of all Betalactams; The Antibacterial Mechanism of Betalactams; Penicillins; Penicillins with an Enlarged Spectrum; Penicillins Stable to Penicillinases; Counteracting Resistance by the Inhibition of Betalactamases; Other Antibacterial Betalactams; Cephalosporins; Monobactams; Thienamycins; Betalactamases; Horizontal Spread of Betalactamases; Penicillin-Binding Proteins; Resistance to Betalactams by Changes in the PBPs 327 $aA Very Old Prophecy Came True5 GLYCOPEPTIDES; Mechanism of Antibacterial Action; Resistance; Avoparcin and Clinical Resistance to Glycopeptides; Vancomycin as an Antibiotic of Last Resort; 6 AMINOGLYCOSIDES; The Antibacterial Mechanism of Streptomycin; Bactericidal Effect; Clinical Side Effects; Bacterial Resistance to Aminoglycosides; Horizontal Spread of Aminoglycoside Resistance; Conclusion; 7 OTHER ANTIBIOTICS INTERFERING WITH BACTERIAL PROTEIN SYNTHESIS; Chloramphenicol; Clinical Side Effects; Bacterial Resistance to Chloramphenicol; Tetracyclines; Mechanism of Action 327 $aClinical Side Effects 330 $aThis book, which is the translated version of a Swedish book, combines a general introduction of a variety of antibiotics with a more in-depth discussion of resistance. The focus on resistance in learning about antibiotics will help future scientists recognize the problem antibiotics resistance poses for medicinal and drug-related fields, and perhaps trigger more research and discoveries to fight antibiotic resistant strains. Current overviews of the topic are included, along with specific discussions on the individual mechanisms (betalactams, glycopeptides, aminoglycosides, etc) used in var 606 $aAntibiotics 606 $aDrug resistance in microorganisms 615 0$aAntibiotics. 615 0$aDrug resistance in microorganisms. 676 $a615/.329 700 $aSkl?d$b Ola$0912598 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910137562803321 996 $aAntibiotics and antibiotic resistance$92043900 997 $aUNINA