LEADER 04487nam 2200625 450 001 9910137537603321 005 20230621135628.0 010 $a9782889195619$b(ebook) 035 $a(CKB)3710000000569645 035 $a(SSID)ssj0001682833 035 $a(PQKBManifestationID)16508031 035 $a(PQKBTitleCode)TC0001682833 035 $a(PQKBWorkID)15037148 035 $a(PQKB)10249234 035 $a(WaSeSS)IndRDA00056605 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54470 035 $a(EXLCZ)993710000000569645 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeural circuits revealed /$fedited by Mariano Soiza-Reilly, Peter Saggau and Benjamin R. Arenkiel 210 $cFrontiers Media SA$d2015 210 31$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (181 pages) $cillustrations; digital file(s) 225 1 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aThe appropriate function of the nervous system relies on precise patterns of connectivity among hundreds to billions of neurons across different biological systems. Evolutionary conserved patterns of neural circuit organization and connectivity between morphologically and functionally diverse sets of neurons emerge from a remarkably robust set of genetic blueprints, uniquely defining circuits responsible for planning and execution of behavioral repertoires. Although it is well established that individual neurons represent the elemental building blocks of the brain, understanding the architecture of neural circuits and how neurons functionally ?wire up? through synapses, remains one of biology?s major challenges. Our current understanding of how interconnected neuronal populations produce perception, memory, and behavior remains nascent. To unravel the details of complex nervous system function, we must consider not only the morphological and physiological properties of individual neurons, but also the structure and function of connections formed between different cell types.Recent advances in molecular genetic, viral engineering, and imaging technologies allow to precisely label, manipulate, and map neural circuits, revealing previously unattainable details about the cellular morphologies and subcellular structures that are unique to the different types of neurons that make up the brain. Examples include newly engineered tools for chemical/genetic labeling and multi-photon imaging, which allow examining the functional connectivity between selective populations of neurons. Another remarkable advance in imaging technologies has been the development of array tomography, a high-resolution immunofluorescence technique that allows the molecular characterization of synapses alongside quantitative analysis of spatial relationships between multiple synaptic components in the same volume of tissue. Now, with such tools in hand, we are able to address long-standing unanswered questions about the structural and functional features of neural circuits.This Research Topic broadly covers studies using state-of-the-art genetic approaches and optical tools to map and explore the functional architecture of neural circuits across various biological systems. Contributions should be made by neuroscientists interested in understanding the structure and function of neural circuits at any level, from micro- to macrocircuits. 410 0$aFrontiers Research Topics. 606 $aNeuroscience$2HILCC 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aoptogenetics 610 $aneuronal tracing 610 $aElectrophysiology 610 $aconnectome 610 $aBehavior 610 $aNeurological and Psychiatric Disorders 610 $aultrastructure 610 $anetworks 615 7$aNeuroscience 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 700 $aMariano Soiza Reilly$4auth$01366257 702 $aSoiza-Reilly$b Mariano 702 $aArenkiel$b Benjamin R 702 $aSaggau$b Peter 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137537603321 996 $aNeural circuits revealed$93388741 997 $aUNINA