LEADER 00966nam--2200337---450- 001 990001123220203316 005 20030529110705.0 035 $a000112322 035 $aUSA01000112322 035 $a(ALEPH)000112322USA01 035 $a000112322 100 $a20030110d2001----km-y0enga50------ba 101 0 $aeng 102 $aSG 105 $ay|||z|||001yy 200 1 $aEast Timor and the Region$fJosè Ramos-Horta 210 $aSingapore$cInstitute of Southeast Asian studies$d2001 215 $a21 p.$d30 cm 606 0 $aTimor 676 $a959.86 700 1$aRAMOS-HORTA,$bJosè$0554677 801 0$aIT$bsalbc$gISBD 912 $a990001123220203316 951 $aIG VIII 10 707/1$b34781 G.$cIG VIII$d00095031 959 $aBK 969 $aGIU 979 $aMARIA$b10$c20030110$lUSA01$h1216 979 $aRENATO$b90$c20030529$lUSA01$h1107 979 $aPATRY$b90$c20040406$lUSA01$h1717 996 $aEast Timor and the Region$9981754 997 $aUNISA LEADER 03651nam 2200637 450 001 9910137533703321 005 20230621141321.0 010 $a9782889195565 (ebook) 035 $a(CKB)3710000000569661 035 $a(SSID)ssj0001695634 035 $a(PQKBManifestationID)16546698 035 $a(PQKBTitleCode)TC0001695634 035 $a(PQKBWorkID)15066458 035 $a(PQKB)25091943 035 $a(WaSeSS)IndRDA00058398 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/48349 035 $a(EXLCZ)993710000000569661 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aGene function in schistosomes $erecent advances towards a cure /$fedited by: Arnon Dias Jurberg and Paul J. Brindley 210 $cFrontiers Media SA$d2015 210 31$aSwitzerland :$cFrontiers Media SA,$d2015 215 $a1 online resource (154 pages) $cillustrations 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 320 $aIncludes bibliographical references. 330 $aSchistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa, urogenital tract diseases, in addition to cardiopulmonary, renal and neurologic lesions due to egg accumulation in the liver, intestines, uro-genital tissues and other sites. Urogenital schistosomiasis is a risk factor for bladder cancer and increases the risk of transmission of HIV infection.Despite extensive effort to control this NTD over the years, deployment on a considerable scale of commercially available drugs in endemic populations has induced the emergence of resistant isolates and raised the need to identify new targets for alternative therapies. Because of the availability of genomes of the three major species of human schistosomiasis, and through advances in functional genomics and live imaging, studies on schistosomes have now come into focus as models to investigate adaptations to parasitism and developmental biology of trematodes and cestodes, and indeed flatworms and Lophotrochozoans, at large.This Research Topic aims at gathering state-of-art essays on schistosome genetics, genetics, pathobiology and immunobiology. It also aims to highlight advances in understanding of the host-parasite relationship, in paradigms that address this NTD, and to discuss new perspectives and advances in chemotherapy and immunoprophylaxis. 606 $aCommunicable Diseases$2HILCC 606 $aPublic Health$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aSchistosomiasis 610 $aSchistosoma mansoni 610 $aS japonicum 610 $aneglected tropical diseases 610 $ainfection induced cancer 610 $aAnthelmintic drugs 610 $aS haematobium 610 $aBlood fluke 610 $aVaccines 610 $aHelminthiasis 615 7$aCommunicable Diseases 615 7$aPublic Health 615 7$aHealth & Biological Sciences 700 $aArnon Dias Jurberg$4auth$01367192 702 $aJurberg$b Arnon Dias 702 $aBrindley$b Paul J 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137533703321 996 $aGene function in schistosomes$93389922 997 $aUNINA