LEADER 03993nam 2200565 450 001 9910137532003321 005 20230621140726.0 010 $a9782889195633 (ebook) 035 $a(CKB)3710000000569670 035 $a(SSID)ssj0001666204 035 $a(PQKBManifestationID)16455520 035 $a(PQKBTitleCode)TC0001666204 035 $a(PQKBWorkID)15000739 035 $a(PQKB)10802969 035 $a(WaSeSS)IndRDA00056079 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42186 035 $a(EXLCZ)993710000000569670 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aBiofilm formation by staphylococci and streptococci$b[electronic resource] $estructural, functional and regulatory aspects and implications for pathogenesis /$fedited by Joan A. Geoghegan and Pietro Speziale 210 $cFrontiers Media SA$d2015 210 31$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (111 pages) $cillustrations 225 0 $aFrontiers Research Topics,$x1664-8714 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aMembers of the genus Staphylococcus and Streptococcus are the causative agnets of many human and animal diseases. Over the past decade the complete sequencing of many staphylococcal and streptococcal genomes has promoted a significant advance in our knowledge of these important pathogens. The pathogenicity of these bacteria is due to the expression of a large variety of virulence factors. Such determinants, which are cell wall-associated and secreted proteins, include adhesins that confer to the pathogen the ability to attach to extracellular matrix/plasma and host cell surfaces, proteins that contribute to host cell invasion and intracellular survival and soluble factors that decrease phagocytosis and modulate the immune response. Furthermore, these Gram-positive cocci in many natural environments (heart valve, lung, oral cavity, throat) and infections on implanted devices live in matrix-encased groups known as biofilms. Biofilms are specialized bacterial communities with high order organization analogous to that of a tissue in multicellular organism that adhere to abiotic or biological substrata and produce an exopolymeric matrix composed of polysaccarides, proteins, DNA or combination thereof. Bacteria within a biofilm persist in adverse conditions, show resistance to killing by antibiotics and to host immune defences and are difficult to eradicate and treat clinically. Therefore, understanding the mechanisms of biofilm development will allow us to effectively combat staphylococcal/streptococcal biofilm-based infections. This Research Topic will focus on the molecular components involved in biofilm formation by staphylococci and streptococci, the role they play in the development, maturation and dispersal of biofilm and on the regulatory aspects of such complex processes. The implication for the pathogenesis of infective diseases and potential therapeutic strategies against biofilm-based infections will be also discussed. The articles will highlight both the recent advances and future challenges inherent in this rapidly evolving area. 606 $aMicrobiology & Immunology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aStreptococcus 610 $aPathogenesis 610 $acolonization 610 $aBiofilm 610 $aStaphylococcus 615 7$aMicrobiology & Immunology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aPietro Speziale$4auth$01365330 702 $aGeoghegan$b Joan A 702 $aSpeziale$b Pietro 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137532003321 996 $aBiofilm formation by staphylococci and streptococci$93387034 997 $aUNINA