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035   $a(CKB)3710000000569674
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/41301
035   $a(EXLCZ)993710000000569674
100   $a20160125h20152015  fy|            0
101 0 $aeng
135   $aurmu#---uuuuu
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aArrest chemokines$b[electronic resource] /$ftopic editor: Klaus Ley
210   $cFrontiers Media SA$d2015
210  1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2015
210  4$d©2015
215   $a1 online resource (108 pages) $cillustrations; digital, PDF file(s)
225 1 $aFrontiers Research Topics
225 1 $aFrontiers in Immunology
311   $a2-88919-430-2 
320   $aIncludes bibliographical references.
330 3 $aArrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparan sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial. Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. Here we present a series of ten reports that help clarify this crucial first step in the process of leukocyte transendothelial migration.
410  0$aFrontiers research topics.
410  0$aFrontiers in immunology.
606   $aChemokines$xImmunology
606   $aImmunologic diseases
606   $aImmunology
610   $achemokine
610   $aLFA-1
610   $aSignal Transduction
610   $aTalin
610   $aintegrin
610   $aleukocyte adhesion
610   $aVLA-4
610   $aKindlin-3
615  0$aChemokines$xImmunology.
615  0$aImmunologic diseases.
615  0$aImmunology.
700   $aKlaus Ley$4auth$01365936
702   $aLey$b Klaus$f1957-
712 02$aFrontiers Research Foundation,
801  2$bUkMaJRU
906   $aBOOK
912   $a9910137531103321
996   $aArrest chemokines$93388229
997   $aUNINA