LEADER 03390nam 2200565 450 001 9910137530103321 005 20230621141054.0 010 $a9782889194360 (ebook) 035 $a(CKB)3710000000569679 035 $a(SSID)ssj0001680277 035 $a(PQKBManifestationID)16496236 035 $a(PQKBTitleCode)TC0001680277 035 $a(PQKBWorkID)15028533 035 $a(PQKB)11169741 035 $a(WaSeSS)IndRDA00057606 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46350 035 $a(EXLCZ)993710000000569679 100 $a20160829d2015 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aEndoplasmic reticulum stress response and transcriptional reprogramming /$ftopic editor Kezhong Zhang 210 $cFrontiers Media SA$d2015 210 31$aSwitzerland :$cFrontiers Media SA,$d2015 215 $a1 online resource (97 pages) $cillustrations 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aEndoplasmic reticulum (ER) is an intracellular organelle responsible for protein folding and assembly, lipid and sterol biosynthesis, and calcium storage. A number of biochemical, physiological, or pathological stimuli can interrupt protein folding process, causing accumulation of unfolded or misfolded proteins in the ER lumen, a condition called ?ER stress?. To cope with accumulation of unfolded or misfolded proteins, the ER has evolved a group of signaling pathways termed ?Unfolded Protein Response (UPR)? or ?ER stress response? to align cellular physiology. To maintain ER homeostasis, transcriptional regulation mediated through multiple UPR branches is orchestrated to increase ER folding capacity, reduce ER workload, and promote degradation of misfolded proteins. In recent years, accumulating evidence suggests that ER stress-triggered transcriptional reprogramming exists in many pathophysiological processes and plays fundamental roles in the initiation and progression of a variety of diseases, such as metabolic disease, cardiovascular disease, neurodegenerative disease, and cancer. Understanding effects and mechanisms of ER stress-associated transcriptional reprogramming has high impact on many areas of molecular genetics and will be particularly informative to the development of pharmacologic avenues towards the prevention and treatment of modern common human diseases by targeting the UPR signaling. For these reasons, ER stress response and transcriptional reprogramming are a timely and necessary topic of discussion for Frontiers in Genetics. 606 $aCytology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aER stress 610 $aInflammation 610 $aTranscriptional reprogramming 610 $aUnfolded Protein Response 610 $aMetabolism 610 $aOncogenes 615 7$aCytology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aKezhong Zhang$4auth$01365044 702 $aZhang$b Kezhong 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137530103321 996 $aEndoplasmic reticulum stress response and transcriptional reprogramming$93386701 997 $aUNINA