LEADER 03645nam 2200625 450 001 9910137494203321 005 20230807211326.0 010 $a1-118-32348-3 010 $a1-118-32343-2 010 $a1-118-32347-5 035 $a(CKB)3710000000576488 035 $a(EBL)4335873 035 $a(SSID)ssj0001600635 035 $a(PQKBManifestationID)16308341 035 $a(PQKBTitleCode)TC0001600635 035 $a(PQKBWorkID)12768031 035 $a(PQKB)10750742 035 $a(PQKBManifestationID)14279825 035 $a(PQKBWorkID)13976937 035 $a(PQKB)21680891 035 $a(MiAaPQ)EBC4335873 035 $a(DLC) 2015010035 035 $a(Au-PeEL)EBL4335873 035 $a(CaPaEBR)ebr11140622 035 $a(CaONFJC)MIL888568 035 $a(OCoLC)935920174 035 $a(EXLCZ)993710000000576488 100 $a20160122h20152015 uy 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aClinical trials in older people /$fedited by Antonio Cherubini [and five others] ; contributors Heather Allore [and thirty five others] 210 1$aChichester, England :$cWiley Blackwell,$d2015. 210 4$dİ2015 215 $a1 online resource (308 p.) 300 $aDescription based upon print version of record. 311 $a1-118-32349-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aThe exclusion of older subjects from clinical trials : the predict study / Antonio Cherubini, Peter Crome -- Clinical trials in older adults : a point of view from the industry / Susanna Del Signore, Philippe Guillet -- Ethical issues in clinical trials involving older subjects : the right to participate in clinical trials and have access to care; the protection of vulnerable subjects and the issue of informed consent / Emmanuel Hirsch, Paul-Loup Weil-Dubuc -- Mastering the design of clinical trials for older persons : the tension between external validity and feasibility / Luigi Ferrucci, Stephanie Studenski -- Pharmacokinetic and pharmacodynamic studies in older adults / Arduino A Mangoni, Paul AF Jansen, Stephen H.D. Jackson -- The role of comprehensive geriatric assessment of older adults in clinical studies / Graziano Onder, Agnese Collamati, Andrea Poscia, Roberto Bernabei -- Statistical issues in designing and interpreting clinical trials in older adults / Heather Allore, Mark A. Espeland, Michael E. Miller -- Challenges in implementing large-scale clinical trials in moderately functioning older adults / Stephen D. Anton, Sandrine Sourdet, Marco Pahor, & Todd Manini -- Clinical trials in Alzheimer's disease / Julien Delrieu , Bruno Vellas -- Clinical trials in late-life mood disorders / Lucio Ghio, Werner Natta, Marco Vaggi, Luigi Ferrannini -- Clinical trials for conditions of low muscle mass and strength / Stephanie Studenski, Rosaly Correa-de-Araujo and Luigi Ferrucci -- Clinical trials of cancer treatment in the elderly / Lodovico Balducci, Iordanis Gravanis, Francesco Pignatti -- Clinical trials in nursing homes : challenges and practical solutions / Sandra Simmons, Barbara Resnik, John Schnelle, Joe Ouslander. 606 $aClinical trials 606 $aGerontology$xResearch 615 0$aClinical trials. 615 0$aGerontology$xResearch. 676 $a610.72/40846 702 $aCherubini$b Antonio$f1966- 702 $aAllore$b Heather 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910137494203321 996 $aClinical trials in older people$92067230 997 $aUNINA