LEADER 03322nam 2200481zu 450 001 9910137239903321 005 20210807004915.0 035 $a(CKB)3710000000506260 035 $a(SSID)ssj0001683362 035 $a(PQKBManifestationID)16509606 035 $a(PQKBTitleCode)TC0001683362 035 $a(PQKBWorkID)15038063 035 $a(PQKB)10637832 035 $a(WaSeSS)IndRDA00056627 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54488 035 $a(oapen)doab54488 035 $a(EXLCZ)993710000000506260 100 $a20160829d2015 uy 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNeuroactive metabolites of ethanol : a behavioral and neurochemical synopsis 210 $cFrontiers Media SA$d2015 210 31$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2015 215 $a1 online resource (126 pages) 225 0 $aFrontiers Research Topics,$x1664-8714 300 $aBibliographic Level Mode of Issuance: Monograph 311 08$a2-88919-375-6 320 $aIncludes bibliographical references. 330 $aEthanol is a very elusive drug, which has mechanisms of action that are diverse and relatively non-selective. Moreover, ethanol has been demonstrated to be a biologically active substance by itself, but also a pro-drug of the neuroactive metabolites, acetaldehyde and acetate. Acetaldehyde has traditionally been known as a toxic substance with several effects on multiple systems. However, in the last few decades evidence has accumulated to reveal the specific and, in some instances, distinct neural actions of acetaldehyde and acetate that are in part responsible for some of the observed psychoactive effects of ethanol. The present issue will address these challenges to provide an up-to-date synopsis of the behavioral and neurophysiological impact of the two direct metabolites of ethanol, acetaldehyde and acetate. In doing so, this issue will present human and rodent evidence on their behavioral and neurophysiological impact, either when administered alone as drugs, or when metabolically-derived from their parent compound. Emphasis will be placed to stress the importance of the different enzymatic systems that intervene to produce these metabolites, either peripherally and/or directly in the brain. Similarly, this Research Topic will be aimed at addressing some of the possible mechanisms of action of acetaldehyde and acetate in different brain areas and in different intracellular systems. Furthermore, the issue will lay out some of the suggested mechanisms of action of ethanol and of its metabolites by which they form adducts with other molecules and neurotransmitters such as dopamine and opioids (which lead to salsolinol and tetrahydropapaveroline, respectively), and their impact on the synthesis and actions of neuromodulators such as adenosine and the cannabinoid system. 606 $aEthanol 615 0$aEthanol. 700 $aElio Acquas$4auth$01287678 702 $aSalamone$b J. D$g(John D.), 702 $aAcquas$b Elio 702 $aCorrea$b Mercè 801 0$bPQKB 906 $aBOOK 912 $a9910137239903321 996 $aNeuroactive metabolites of ethanol : a behavioral and neurochemical synopsis$94418168 997 $aUNINA