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010   $a9782889193622 (ebook)
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035   $a(PQKBTitleCode)TC0001680271
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035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46253
035   $a(EXLCZ)993710000000506272
100   $a20160829d2014      uy|            0
101 0 $aeng
135   $aur|||||||||||
181   $ctxt
182   $cc
183   $acr
200 00$aEmerging immune functions of non-hematopoietic stromal cells /$ftopic editors: Christopher G. Mueller, Paul Kaye, Mark C. Coles and Burkhard Ludewig
210   $cFrontiers Media SA$d2014
210 31$aSwitzerland :$cFrontiers Media SA,$d2014
215   $a1 online resource (161 pages) $cillustrations
225 0 $aFrontiers Research Topics
300   $aBibliographic Level Mode of Issuance: Monograph
320   $aIncludes bibliographical references.
330   $aThe development and function of the immune system is dependent on interactions between haematopoietic cells and non-hematopoietic stromal cells. The non-hematopoietic stromal cells create the microenvironment in which the immune system operates, providing an architectural landscape for hematopoietic cell-cell interactions and molecular cues governing haematopoietic cell positioning, growth and survival. Not surprisingly, therefore, aberrant stromal cell function has recently been shown to play a key role in the development of disease pathologies associated with immune dysfunction. For example, remodelling of lymphoid tissue stroma and the development of ectopic tertiary lymphoid tissues are characteristic of many infectious and inflammatory diseases and stromal cells have a recognised role in lymphoma and tumour development and resistance to therapy. An increased understanding of the molecular basis of stromal cell differentiation and function in these varied contexts will provide new tools to promote research on stromal cell biology and immune dysfunction, and potential new targets for therapeutic intervention in diseases with a major impact on public health. The importance of stromal cells and the molecular mechanisms of stromal cell function in the regulation of immune responses have only recently been appreciated and thus represent an exciting new area in immunology.
606   $aClinical Immunology$2HILCC
606   $aMedicine$2HILCC
606   $aHealth & Biological Sciences$2HILCC
610   $adevelopment
610   $aendothelial cells
610   $alymphoid tissue
610   $ainflammation
610   $afibroblast reticular cells
615  7$aClinical Immunology
615  7$aMedicine
615  7$aHealth & Biological Sciences
676   $a616.97
700   $aMark Christopher Coles$4auth$01364867
702   $aKaye$b Paul
702   $aMueller$b Christopher G
702   $aColes$b Mark C
801  0$bPQKB
801  2$bUkMaJRU
912   $a9910137235403321
996   $aEmerging immune functions of non-hematopoietic stromal cells$93386310
997   $aUNINA