LEADER 03001nam 2200457zu 450 001 9910137234603321 005 20230807201830.0 035 $a(CKB)3710000000506274 035 $a(SSID)ssj0001683372 035 $a(PQKBManifestationID)16509560 035 $a(PQKBTitleCode)TC0001683372 035 $a(PQKBWorkID)15038024 035 $a(PQKB)10715461 035 $a(WaSeSS)IndRDA00056681 035 $a(EXLCZ)993710000000506274 100 $a20160829d2015 uy 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aNever-resting microglia : physiological roles in the healthy brain and pathological implications 210 31$a[Place of publication not identified]$cFrontiers Media SA$d2015 215 $a1 online resource (172 pages) 225 0 $aFrontiers Research Topics,$x1664-8714 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aMicroglia are largely known as the major orchestrators of the brain inflammatory response. As such, they have been traditionally studied in various contexts of disease, where their activation has been assumed to induce a wide range of detrimental effects. In the last few years, a series of discoveries have challenged the current view of microglia, showing their active and positive contribution to normal brain function. This Research Topic will review the novel physiological roles of microglia in the developing, mature and aging brain, under non-pathological conditions. In particular, this Research Topic will discuss the cellular and molecular mechanisms by which microglia contribute to the formation, pruning and plasticity of synapses; the maintenance of the blood brain barrier; the regulation of adult neurogenesis and hippocampal learning; and neuronal survival, among other important roles. Because these novel findings defy our understanding of microglial function in health as much as in disease, this Research Topic will also summarize the current view of microglial nomenclature, phenotypes, origin and differentiation, sex differences, and contribution to various brain pathologies. Additionally, novel imaging approaches and molecular tools to study microglia in their non-activated state will be discussed. In conclusion, this Research Topic seeks to emphasize how the current research in neuroscience is challenged by never-resting microglia. 606 $aNeuroscience$2HILCC 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 615 7$aNeuroscience 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 702 $aSierra$b Amanda 702 $aWake$b Hiroaki 702 $aTremblay$b Marie-Ève 801 0$bPQKB 912 $a9910137234603321 996 $aNever-resting microglia : physiological roles in the healthy brain and pathological implications$92040155 997 $aUNINA