LEADER 03737oam 2200493z 450 001 9910137222103321 005 20221206175759.0 035 $a(CKB)3710000000520097 035 $a(SSID)ssj0001666196 035 $a(PQKBManifestationID)16455617 035 $a(PQKBTitleCode)TC0001666196 035 $a(PQKBWorkID)15000834 035 $a(PQKB)10835630 035 $a(WaSeSS)IndRDA00056026 035 $a(EXLCZ)993710000000520097 100 $a20160829d2014 fy 0 101 0 $aeng 135 $aurmn#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBeyond the borders $ethe gates and fences of neuroimmune interaction /$ftopic editors Javier Velázquez-Moctezuma, Emilio Domínguez-Salazar and Beatriz Gómez-González 210 1$aLausanne, Switzerland :$cFrontiers Media SA,$d2014. 210 4$d©2014 215 $a1 online resource (119 pages) $ccharts; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a2-88919-274-1 320 $aIncludes bibliographical references. 327 $aBeyond the borders: the gates and fences of neuroimmune interaction --Section 1 --Section 2 --Section 3 --Section 4. 330 3 $aNeuroimmunology is a rapidly growing emerging field at which two old sciences have converged to integrate two different types of responses into a single coherent response involving the coordinated action of both systems, neural and immune. During long time it was thought that both systems worked separately and in divergent pathways. The brain was considered an immunoprivileged site and the immune organs were deemed as independent of any neural influence and also of nervous innervation. Time has gone and has proven that the borders between both systems were merely artificial. Since the beginning of Neuroimmunology in the 1980s much work has been done to elucidate the gates and fences in neuro-immune interactions. Brain was shown to be under the continuous surveillance of the immune system, even under basal physiological conditions in the absence of any pathology. Likely, it was found a profuse nervous innervation of lymphoid organs and even of single immune cells. Gates for direct neural immune communication were found both centrally and peripherally. Centrally, the gates, but also the fences, were situated at the brain barriers, the blood-brain barrier and the blood-cerebrospinal fluid barrier, and at the circunventricular organs. Peripherally, the fences constituted the apparent diverse nature of molecules involved in neural and immune signaling; however, time proved that both system were capable of producing the same signaling molecules and also systematically responded to the molecules released by the other system. Therefore, the gates were open for direct neural-immune communication at the peripheral level. This Research Topic aims to include original reports, reviews and technical reports regarding the description of the gates and fences in neural immune interactions. We intend to provide an extensive view of the mechanisms governing central and peripheral neural-immune interactions, and the role of the borders, the blood-neural barriers, in the regulation of the neural-immune communication. 606 $aNeuroscience 606 $aNeuroimmunology 615 0$aNeuroscience. 615 0$aNeuroimmunology. 702 $aVelázquez-Moctezuma$b Javier 702 $aGómez-González$b Beatriz 702 $aDomínguez-Salazar$b Emilio 801 0$bPQKB 801 2$bUkMaJRU 906 $aBOOK 912 $a9910137222103321 996 $aBeyond the borders$92233977 997 $aUNINA