LEADER 04869nam 2200733 450 001 9910137218803321 005 20230621141305.0 035 $a(CKB)3710000000520106 035 $a(SSID)ssj0001669419 035 $a(PQKBManifestationID)16459305 035 $a(PQKBTitleCode)TC0001669419 035 $a(PQKBWorkID)15002919 035 $a(PQKB)11517963 035 $a(WaSeSS)IndRDA00056844 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44286 035 $a(EXLCZ)993710000000520106 100 $a20160829d2015 fy 0 101 0 $aeng 135 $aurmu#---uuuuu 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCriticality as a signature of healthy neural systems$b[electronic resource] $emulti-scale experimental and computational studies /$ftopic editors Paolo Massobrio, Lucilla de Arcangelis, Valentina Pasquale, Henrik J. Jensen and Dietmar Plenz 210 $cFrontiers Media SA$d2015 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d2015 215 $a1 online resource (139 pages) $cillustrations; digital, PDF file(s) 225 1 $aFrontiers Research Topics 225 1 $aFrontiers in Systems Neuroscience 300 $aBibliographic Level Mode of Issuance: Monograph 311 $a2-88919-503-1 320 $aIncludes bibliographical references. 330 3 $aSince 2003, when spontaneous activity in cortical slices was first found to follow scale-free statistical distributions in size and duration, increasing experimental evidences and theoretical models have been reported in the literature supporting the emergence of evidence of scale invariance in the cortex. Although strongly debated, such results refer to many different in vitro and in vivo preparations (awake monkeys, anesthetized rats and cats, in vitro slices and dissociated cultures), suggesting that power law distributions and scale free correlations are a very general and robust feature of cortical activity that has been conserved across species as specific substrate for information storage, transmission and processing. Equally important is that the features reminiscent of scale invariance and criticality are observed at scale spanning from the level of interacting arrays of neurons all the way up to correlations across the entire brain. Moreover, the existing relationship between features of structural connectivity and functional critical states remains partly unclear, although investigated with both analyses of experimental data and in silico models. Thus, if we accept that the brain operates near a critical point, little is known about the causes and/or consequences of a loss of criticality and its relation with brain diseases (e.g. epilepsy). The study of how pathogenetical mechanisms are related to the critical/non-critical behavior of neuronal networks would likely provide new insights into the cellular and synaptic determinants of the emergence of critical-like dynamics and structures in neural systems. At the same time, the relation between the impaired behavior and the disruption of criticality would help clarify its role in normal brain function. The main objective of this Research Topic is to investigate the emergence/disruption of the emergent critical-like states in healthy/impaired neural systems and to link these phenomena to the underlying cellular and network features, with specific attention to structural connectivity. In particular, we would like this Research Topic to collect contributions coming from the study of neural systems at different levels of architectural complexity (from in vitro neuronal ensembles up to the human brain imaged by fMRI). 410 0$aFrontiers research topics. 410 0$aFrontiers in systems neuroscience. 606 $aNeurosciences 606 $aNervous system 606 $aNeuroscience$2HILCC 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aComputational models 610 $ain vitro 610 $ain vivo 610 $anetwork dynamics 610 $aself-organized criticality 610 $aneuronal avalanches 610 $apower law 615 0$aNeurosciences. 615 0$aNervous system. 615 7$aNeuroscience 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 700 $aDietmar Plenz$4auth$01365907 702 $aMassobrio$b Paolo 702 $aArcangelis$b Lucilla de 702 $aPasquale$b Valentina 702 $aJensen$b Henrik Jeldtoft$f1956- 702 $aPlenz$b Dietmar 712 02$aFrontiers Research Foundation, 801 0$bPQKB 801 2$bUkMaJRU 906 $aBOOK 912 $a9910137218803321 996 $aCriticality as a signature of healthy neural systems$93387997 997 $aUNINA