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035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55562
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100   $a20160829d2015      uy             0
101 0 $aeng
135   $aur||#||||||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aPAIN - Novel targets and new technologies /$ftopic editors, Susan Hua and Peter J. Cabot
210   $cFrontiers Media SA$d2015
210 31$aFrance :$cFrontiers Media SA,$d2015
215   $a1 online resource (95 pages) $cdigital, PDF file(s)
225 1 $aFrontiers Research Topics
300   $aBibliographic Level Mode of Issuance: Monograph
320   $aIncludes bibliographical references.
330   $aThe problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. For example, peripheral endogenous analgesia can be elicited by immune cells entering inflamed tissue and releasing opioid peptides that activate up-regulated opioid receptors on sensory nerve terminals. Such analgesic effects are particularly prominent in painful inflammatory conditions and avoid central opioid side effects. In this Research Topic of Frontiers, we would like to bring together experts in the field of pain at the physiological, pharmacological and pharmaceutical levels to discuss novel pain targets and new pain technologies. The goal of this workshop is to generate collaborative discussion on the future and direction of pain therapies. Manuscripts describing original research, methods, hypothesis and theory, and reviews are welcomed.
606   $aPathology$2HILCC
606   $aMedicine$2HILCC
606   $aHealth & Biological Sciences$2HILCC
610   $aPain
610   $aAnalgesics
610   $aTargeted Drug Delivery
610   $anovel strategies
610   $aTherapeutic target
615  7$aPathology
615  7$aMedicine
615  7$aHealth & Biological Sciences
700   $aPeter John Cabot$4auth$01366719
702   $aHua$b Susan
702   $aCabot$b Peter J
801  0$bPQKB
801  2$bUkMaJRU
912   $a9910137209503321
996   $aPAIN - Novel targets and new technologies$93389325
997   $aUNINA