LEADER 04390nam 2200625 450 001 9910137208103321 005 20230621140404.0 010 $a9782889195145$b(ebook) 035 $a(CKB)3710000000526077 035 $a(SSID)ssj0001666219 035 $a(PQKBManifestationID)16455412 035 $a(PQKBTitleCode)TC0001666219 035 $a(PQKBWorkID)15000816 035 $a(PQKB)11549940 035 $a(WaSeSS)IndRDA00056217 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42423 035 $a(EXLCZ)993710000000526077 100 $a20160829d2015 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdamedia 200 00$aBrain-immune interactions in health and disease /$ftopic editors: Adam Denes and Jaleel A. Miyan 210 $cFrontiers Media SA$d2015 210 31$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (109 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aRegulation of defence mechanisms in the body is maintained via bi-directional interactions between the nervous- and immune systems. Recent development of multidisciplinary approaches enabled some insight into the complexity of these interactions although control of immunity by the nervous system is still poorly understood. Nevertheless, inadequate regulation of inflammatory processes is increasingly linked to acute and chronic diseases in which the active role of the central nervous system is emerging. Insufficient immune activation contributes to the development of infections or cancer, whilst excessive immune activation is associated with acute and chronic inflammatory diseases, such as autoimmune conditions, septic shock, fever or allergies. This indicates that feedback regulation of immune function must exist to prevent either eventuality under optimum conditions. More recently, chronic inflammation has been identified as a driver for several non-communicable diseases such as atherosclerosis, hypertension, obesity or diabetes that are also primary risk factors for acute cardio- and cerebrovascular events. In these conditions, altered function of neuroendocrine and autonomic systems is now also recognised, and contributes to / influenced by altered production of inflammatory mediators, such as Interleukin 1 (IL-1). Elevated systemic inflammatory burden is clearly associated with cerebrovascular changes in both patients and experimental animal models and a role for the central nervous system in driving systemic inflammatory changes is emerging. Moreover, it is also becoming clear that chronic immune conditions may underlie/precipitate serious neurological conditions including Autism. The scope of this research topic is to facilitate understanding of complex neuro-immune interactions by gathering relevant research papers and review articles. Specifically, we aim to bring together experts in this field, who have contributed substantially to our knowledge about neural regulation of immunity in health, and in common inflammatory diseases that exert significant burden on the society. We believe that research addressing disease mechanisms has to consider the complexity of in vivo systems, and by investigating neuro-immune interactions, this research topic might also contribute to our understanding and facilitate the development of better therapeutic approaches in inflammatory diseases. 606 $aPathology$2HILCC 606 $aMedicine$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aAutoimmunity 610 $abrain-immune interactions 610 $aDisease 610 $aregulation 610 $aBrain Injury 610 $aNeuropeptides 610 $aInflammation 610 $aautism 610 $apsychiatric disorders 610 $aAsthma 615 7$aPathology 615 7$aMedicine 615 7$aHealth & Biological Sciences 700 $aAdam Denes$4auth$01366157 702 $aDenes$b Adam 702 $aMiyan$b J. A$g(Jaleel A.) 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137208103321 996 $aBrain-immune interactions in health and disease$93388680 997 $aUNINA LEADER 03004oas 2201009 a 450 001 9910800027903321 005 20251106213014.0 011 $a3065-5218 035 $a(DE-599)ZDB2607235-X 035 $a(OCoLC)919520045 035 $a(CONSER) 2024203225 035 $a(CKB)110978979592037 035 $a(EXLCZ)99110978979592037 100 $a20150901a19849999 ub a 101 0 $aeng 135 $aurun||||a|a|| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 14$aThe folklore historian 210 $aMiddletown, Pa. $cFolklore and American Studies, Pennsylvania State University$d1984- 210 2 $aTerre Haute, Ind. $cDepartment of English, Indiana State University in cooperation with the Hoosier Folklore Society 210 3 $aUniversity Park, PA $cPenn State University Libraries 215 $a1 online resource (volumes) 300 $aEditor: S.J. 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