LEADER 03634nam 2200589 450 001 9910137207303321 005 20230621140717.0 010 $a9782889193899$b(ebook) 035 $a(CKB)3710000000520132 035 $a(SSID)ssj0001680367 035 $a(PQKBManifestationID)16496297 035 $a(PQKBTitleCode)TC0001680367 035 $a(PQKBWorkID)15028482 035 $a(PQKB)11329923 035 $a(WaSeSS)IndRDA00056405 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53983 035 $a(EXLCZ)993710000000520132 100 $a20160829d2014 uy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMotor cortex microcircuits $e(Frontiers in brain microcircuits series) /$ftopic editors: Michael Brecht, Nicholas Hatsopoulos,Takehsi Kaneko and Gordon M. G. Shepherd 210 $cFrontiers Media SA$d2015 210 31$aFrance :$cFrontiers Media SA,$d2014 215 $a1 online resource (133 pages) $cillustrations; digital, PDF file(s) 225 1 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aHow does the motor cortex enable mammals to generate accurate, complex, and purposeful movements? A cubic milimeter of motor cortex contains roughly ?10?5 cells, an amazing ?4 Km of axons and ?0.4 Km of dendrites, somehow wired together with ?10?9 synapses. Corticospinal neurons (a.k.a. Betz cells, upper motor neurons) are a key cell type, monosynaptically conveying the output of the cortical circuit to the spinal cord circuits and lower motor neurons. But corticospinal neurons are greatly outnumbered by all the other kinds of neurons in motor cortex, which presumably also contribute crucially to the computational operations carried out for planning, executing, and guiding actions. Determining the wiring patterns, the dynamics of signalling, and how these relate to movement at the level of specific excitatory and inhibitory cell types is critically important for a mechanistic understanding of the input-output organization of motor cortex. While there is a predictive microcircuit hypothesis that relates motor learning to the operation of the cerebellar cortex, we lack such a microcircuit understanding in motor cortex and we consider microcircuits as a central research topic in the field. This Research Topic covers any issues relating to the microcircuit-level analysis of motor cortex. Contributions are welcomed from neuroscientists at all levels of investigation, from in vivo physiology and imaging in humans and monkeys, to rodent models, in vitro anatomy, electrophysiology, electroanatomy, cellular imaging, molecular biology, disease models, computational modelling, and more. 410 0$aFrontiers Research Topics. 606 $aNeuroscience$2HILCC 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aMotor Cortex 610 $aintracortical connectivity 610 $acorticospinal neurons 610 $adirectional tuning 610 $amotor control 615 7$aNeuroscience 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 700 $aTakehsi Kaneko$4auth$01366029 702 $aKaneko$b Takehsi 702 $aShepherd$b Gordon M 702 $aHatsopoulos$b Nicholas G 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137207303321 996 $aMotor cortex microcircuits$93388486 997 $aUNINA