LEADER 00955nam0-22003611i-450- 001 990001443400403321 010 $a0-387-98466-6 035 $a000144340 035 $aFED01000144340 035 $a(Aleph)000144340FED01 035 $a000144340 100 $a20000920d2000----km-y0itay50------ba 101 0 $aeng 200 1 $aSimultaneos triangularization$fH. Radjavi, P. Rosenthal 210 $aNew York$cSpringer$dc2000 215 $axii, 318 p.$d25 cm 225 1 $aUniversitext 610 0 $aAlgebra lineare e multilineare 610 0 $aTeoria delle matrici 676 $a512.9 700 1$aRadjavi,$bHeydar$058512 702 1$aRosenthal,$bPeter 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990001443400403321 952 $aC-6-(107$b17499$fMA1 959 $aMA1 962 $a15-02 962 $a15A21 962 $a15A30 996 $aSimultaneos triangularization$9374600 997 $aUNINA DB $aING01 LEADER 04116nam 2200625 450 001 9910137205603321 005 20230621140722.0 010 $a9782889192793$b(ebook) 035 $a(CKB)3710000000526086 035 $a(SSID)ssj0001680364 035 $a(PQKBManifestationID)16496324 035 $a(PQKBTitleCode)TC0001680364 035 $a(PQKBWorkID)15028535 035 $a(PQKB)11675584 035 $a(WaSeSS)IndRDA00056395 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53850 035 $a(EXLCZ)993710000000526086 100 $a20160829d2015 uy | 101 0 $aeng 135 $aurc|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMolecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases / 210 $cFrontiers Media SA$d2015 210 31$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (163 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aCytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and chemokine secretion, they can influence other cells of the immune system. Through these processes, cytotoxic lymphocytes also contribute to the maintenance of immune homeostasis. In recent years, much progress has been made with respect to the mechanisms by which cytotoxic lymphocytes develop, differentiate, and exert their effector functions. In a clinical perspective, a wide variety of mutations impairing cytotoxic lymphocyte development and/or function have been associated with immunodeficiency and severe diseases in humans. Aberrant activity of cytotoxic T cells and/or NK cells has been linked to an increased susceptibility to viral infections, persistent inflammation, cancer and autoimmunity. In addition, lymphocyte cytotoxic activity may be harnessed therapeutically to target tumor cells in different adoptive cellular therapy regimes, or through the use of recombinant antibodies. Still, a number of questions remain in regards to how cytotoxic lymphocytes develop, their relationships and plasticity, as well as the mechanisms dictating target cell discrimination, lytic granule release and induction of target cell death. In this Research Topic we encourage submission of research articles, reviews, perspectives, or methods on cytotoxic lymphocyte development and function, their relation to the pathogenesis or treatment of different diseases, as well as comparison between similarities and/or differences in their effector functions. Considering the clinical significance of NK cells and cytotoxic T cells, we aim to provide a range of articles summarizing the current knowledge on the identification and elucidation of the mechanisms governing cytotoxic lymphocyte activity. 606 $aMicrobiology & Immunology$2HILCC 606 $aBiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $asecretory lysosomes 610 $aNK cells 610 $ahemophagocytic histiocytosis 610 $aimmune therapy 610 $agranzyme 610 $alytic granules 610 $aCytotoxicity 610 $aanti-tumor response 610 $aImmunological Synapse 610 $aPerforin 615 7$aMicrobiology & Immunology 615 7$aBiology 615 7$aHealth & Biological Sciences 700 $aKonrad Krzewski$4auth$01364357 702 $aKrzewski$b Konrad 702 $aBryceson$b Yenan 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137205603321 996 $aMolecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases$93385560 997 $aUNINA LEADER 02651nam 2200349 450 001 9910574881403321 005 20230823102049.0 024 7 $a10.1145/3472720 035 $a(CKB)4930000000238509 035 $a(NjHacI)994930000000238509 035 $a(EXLCZ)994930000000238509 100 $a20230823d2021 uy 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProceedings of the 2021 Workshop on Open Challenges in Online Social Networks /$fBarbara Guidi 210 1$aNew York, New York :$cAssociation for Computing Machinery,$d2021. 215 $a1 online resource (39 pages) $cillustrations 311 $a1-4503-8632-6 330 $aIt is our great pleasure to welcome you to the 2021 Workshop on Open Challenges in Online Social Networks - OASIS 2021, held in conjunction with the 2021 ACM Conference on Hypertext and Social Media - ACM HT 2021. The diffusion of Online Social Networks (OSNs) has had a profound effect on the way we interact and a deep impact on society and business. OSNs have helped people to communicate, breaking down the geographical barriers that restricted communication. Through social networks, virtual communication, sharing of information, community participation is possible even among people in uncomfortable conditions. Today, OSNs are one of the main parts of daily life by affecting sociality, but they are also important channels through which information travels faster than ever. Analysis of OSN can help to foresee events to manage critical scenarios. The rapid growth in popularity has opened new challenging problems which involve numerous fields in computer science. These issues have implications on social graph analysis, trust and security, and so on. Moreover, privacy issues and the usage of mobile devices has opened new research fields in the design of decentralised online social networks, which can be considered one of the most important challenges. Furthermore, the current improvement concerning the study and the proposal of new approaches for Social Networks and Media involve not only complex network analysis, and, in particular, the decentralisation of social services, but also the introduction of new AI solutions. 606 $aOnline social networks$vCongresses 615 0$aOnline social networks 676 $a006 700 $aGuidi$b Barbara$01385115 801 0$bNjHacI 801 1$bNjHacl 906 $aBOOK 912 $a9910574881403321 996 $aProceedings of the 2021 Workshop on Open Challenges in Online Social Networks$93432238 997 $aUNINA