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010   $a9782889192793$b(ebook)
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035   $a(PQKBTitleCode)TC0001680364
035   $a(PQKBWorkID)15028535
035   $a(PQKB)11675584
035   $a(WaSeSS)IndRDA00056395
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53850
035   $a(EXLCZ)993710000000526086
100   $a20160829d2015      uy             |
101 0 $aeng
135   $aurc|#---|||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMolecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases /
210   $cFrontiers Media SA$d2015
210 31$aFrance :$cFrontiers Media SA,$d2015
215   $a1 online resource (163 pages) $cillustrations; digital, PDF file(s)
225 0 $aFrontiers Research Topics
300   $aBibliographic Level Mode of Issuance: Monograph
320   $aIncludes bibliographical references.
330   $aCytotoxic lymphocytes, comprised of NK cells and cytotoxic T cells, play a pivotal role in immune defense. By directed release of perforin-containing lytic granules, NK and cytotoxic T cells can eradicate pathogen-infected, tumorigenic, and otherwise stressed cells. By the virtue of cytokine and chemokine secretion, they can influence other cells of the immune system. Through these processes, cytotoxic lymphocytes also contribute to the maintenance of immune homeostasis. In recent years, much progress has been made with respect to the mechanisms by which cytotoxic lymphocytes develop, differentiate, and exert their effector functions. In a clinical perspective, a wide variety of mutations impairing cytotoxic lymphocyte development and/or function have been associated with immunodeficiency and severe diseases in humans. Aberrant activity of cytotoxic T cells and/or NK cells has been linked to an increased susceptibility to viral infections, persistent inflammation, cancer and autoimmunity. In addition, lymphocyte cytotoxic activity may be harnessed therapeutically to target tumor cells in different adoptive cellular therapy regimes, or through the use of recombinant antibodies. Still, a number of questions remain in regards to how cytotoxic lymphocytes develop, their relationships and plasticity, as well as the mechanisms dictating target cell discrimination, lytic granule release and induction of target cell death. In this Research Topic we encourage submission of research articles, reviews, perspectives, or methods on cytotoxic lymphocyte development and function, their relation to the pathogenesis or treatment of different diseases, as well as comparison between similarities and/or differences in their effector functions. Considering the clinical significance of NK cells and cytotoxic T cells, we aim to provide a range of articles summarizing the current knowledge on the identification and elucidation of the mechanisms governing cytotoxic lymphocyte activity.
606   $aMicrobiology & Immunology$2HILCC
606   $aBiology$2HILCC
606   $aHealth & Biological Sciences$2HILCC
610   $asecretory lysosomes
610   $aNK cells
610   $ahemophagocytic histiocytosis
610   $aimmune therapy
610   $agranzyme
610   $alytic granules
610   $aCytotoxicity
610   $aanti-tumor response
610   $aImmunological Synapse
610   $aPerforin
615  7$aMicrobiology & Immunology
615  7$aBiology
615  7$aHealth & Biological Sciences
700   $aKonrad Krzewski$4auth$01364357
702   $aKrzewski$b Konrad
702   $aBryceson$b Yenan
801  0$bPQKB
801  2$bUkMaJRU
912   $a9910137205603321
996   $aMolecular mechanisms regulating cytotoxic lymphocyte development and function and their associations to human diseases$93385560
997   $aUNINA