LEADER 03529nam 2200637 450 001 9910137205303321 005 20230621140344.0 010 $a9782889193844$b(ebook) 035 $a(CKB)3710000000520137 035 $a(SSID)ssj0001683364 035 $a(PQKBManifestationID)16509559 035 $a(PQKBTitleCode)TC0001683364 035 $a(PQKBWorkID)15037989 035 $a(PQKB)10499707 035 $a(WaSeSS)IndRDA00056653 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54492 035 $a(EXLCZ)993710000000520137 100 $a20160829h20152015 fy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeurobiological circuit function and computation of the serotonergic and related systems /$fTopic editors: Kae Nakamura and KongFatt Wong-Lin 210 $cFrontiers Media SA$d2015 210 31$a[Lausanne, Switerland] :$cFrontiers Media SA,$d[2015] 210 4$dİ2015 215 $a1 online resource (165 pages) $cillustrations (black and white, and colour); digital file(s) 225 1 $aFrontiers Research Topics,$x1664-8714 300 $aBibliographic Level Mode of Issuance: Monograph 300 $a"Published in: Frontiers in integrative neuroscience" -- front cover. 311 08$aPrint version: Wong-Lin, KongFatt (editor). Neurobiological circuit function and computation of the serotonergic and related systems. [Lausanne, Switzerland] : Frontiers Media SA, 2015 2889193845 320 $aIncludes bibliographical references. 330 $aSerotonin is one of the oldest neurotransmitters in evolutionary terms, and the serotonergic system is complex and multifaceted. Serotonin-producing neurons in the raphe nuclei provide serotonin innervations throughout various parts of the brain, modulating cellular excitability and network properties of targeted brain areas, and regulating mood, cognition and behavior. Dysfunctions of the serotonergic system are implicated in neuropsychiatric disorders including depression, schizophrenia, and drug abuse. Although the system has been studied for many years, an integrative account of its functions and computational principles remains elusive. This is partly attributed to the high variability and heterogeneity in terms of neuronal properties and receptor types, and its extensive connections with other brain regions. This Frontiers Research Topic e-book is a collection of recent experimental and computational work and approaches at multiple scales that provide the latest information regarding the integrated functions of the serotonergic system. The contributed papers include a variety of experimental and computational work, and human clinical studies. 410 0$aFrontiers research topics. 606 $aSerotonin 606 $aDopamine 610 $adorsal raphe nucleus 610 $aLocus Coeruleus 610 $aneural circuit 610 $aDopamine 610 $aSerotonin 610 $apendunculopontine tegmental nucleus 610 $aserotonin 5-HT 610 $acomputational modeling 615 0$aSerotonin. 615 0$aDopamine. 700 $aKae Nakamura$4auth$01366028 702 $aWong-Lin$b KongFatt 702 $aNakamura$b Kae 801 0$bPQKB 801 2$bUkMaJRU 906 $aBOOK 912 $a9910137205303321 996 $aNeurobiological circuit function and computation of the serotonergic and related systems$93388485 997 $aUNINA