LEADER 02701nam 2200637 450 001 9910137204303321 005 20230621140720.0 010 $a9782889192762 (ebook) 035 $a(CKB)3710000000520140 035 $a(SSID)ssj0001669447 035 $a(PQKBManifestationID)16460535 035 $a(PQKBTitleCode)TC0001669447 035 $a(PQKBWorkID)15003581 035 $a(PQKB)10965825 035 $a(WaSeSS)IndRDA00057007 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44602 035 $a(EXLCZ)993710000000520140 100 $a20160829d2014 uy | 101 0 $aeng 135 $aur||||||||||| 181 $ctxt 182 $cc 183 $acr 200 00$aDeciphering serotonin's role in neurodevelopment /$ftopic editors Judith R. Homberg, Sharon M. Kolkand Dirk Schubert 210 $cFrontiers Media SA$d2014 210 31$aFrance :$cFrontiers Media SA,$d2014 215 $a1 online resource (131 pages) $cillustrations 225 0 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aThis Research Topic is devoted to studies pinpointing the neurodevelopmental effects of serotonin in relation to prenatal SSRI exposure, serotonin transporter gene variation, and autism/neurodevelopmental disorders, using a wide-variety of cellular and molecular neurobiological techniques like, (epi)genetics, knockout, knockdown, neuroanatomy, physiology, MRI and behaviour in rodents and humans. We especially encouraged attempts to cross-link the neurodevelopmental processes across the fields of prenatal SSRI exposure, serotonin transporter gene variation, and autism/neurodevelopmental disorders, as well as new views on the positive or beneficial effects on serotonin-mediated neurodevelopmental changes. 606 $aSerotonin 606 $aSerotonin$xPhysiological effect 610 $aMaternal Depression 610 $aserotonin receptor 610 $aRaphe Nuclei 610 $aSerotonin 610 $aneurodevelopment 610 $aserotonin transporter 610 $asensory system 610 $aplacental serotonin 610 $aautism 610 $aPrefrontal Cortex 610 $acortical integrity 615 0$aSerotonin. 615 0$aSerotonin$xPhysiological effect. 676 $a612.8/042 700 $aSharon M. Kolk$4auth$01366090 702 $aHomberg$b Judith R 702 $aKolk$b Sharon M 702 $aSchubert$b Dirk 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137204303321 996 $aDeciphering serotonin's role in neurodevelopment$93388525 997 $aUNINA LEADER 03770nam 22006495 450 001 9910847585003321 005 20250808093203.0 010 $a3-031-55287-3 024 7 $a10.1007/978-3-031-55287-8 035 $a(CKB)31491609400041 035 $a(MiAaPQ)EBC31276950 035 $a(Au-PeEL)EBL31276950 035 $a(DE-He213)978-3-031-55287-8 035 $a(EXLCZ)9931491609400041 100 $a20240413d2024 u| 0 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aActivation and Detoxification Enzymes $eFunctions and Implications /$fby Chang-Hwei Chen 205 $a2nd ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (257 pages) 311 08$a3-031-55286-5 320 $aIncludes bibliographical references and index. 327 $aOverview -- Foreign Compounds: Foods, Drugs, Chemicals and Life Styles -- Transport and Excretion of Foreign Compounds -- Metabolic Conversion of Foreign Compounds -- Phase I Activation Enzymes -- Phase II Detoxification Enzymes -- Catalytic Reactions of Activation Enzymes -- Catalytic Reactions of Detoxification Enzymes -- Reactive Intermediates and their Interactions -- Metabolite - Associated Cell Toxicities -- Oxidative Stress and Electrophilic Stress -- Metabolic Enzymes: Polymorphism and Species Differences -- Defense Against Oxidative Stress: Nrf2-ARE Pathway -- Inducibility of Metabolic Enzymes -- Inducers of Metabolic Enzymes -- Diversified Classes of Enzyme Modulators -- Metabolite - Mediated Disease Conditions -- Metabolic Enzyme Induction for Health Benefits -- Diet Effects on Metabolic Enzymes. 330 $aThis book discusses the many advances in the understanding of the functions and implications of activation and detoxification enzymes. This organized, concise overview will meet the needs of those who are initially exposed to this important subject, particularly for students and researchers in the areas of biomedical sciences, biochemistry, nutrition, pharmacology, and chemistry. The book will also be valuable to advanced researchers. The book discusses subjects associated with foreign-compound-metabolizing enzymes with emphasis on biochemical aspects, including lipophilic foreign compounds, activation and detoxification enzymes, metabolic enzyme catalytic properties, reactive metabolic intermediates, biomedical and biochemical effects, genetic polymorphisms, enzyme inducibility, enzyme modulation for health benefits, dietary-related enzyme modulators, and structural characteristics of enzyme inducers. This new edition is updated throughout and features completely new chapters on Oxidative and Electrophilic Stresses, Metabolite- Mediated Disease Conditions, and Defense Mechanism: Nrf2-ARE Pathway. . 606 $aHuman physiology 606 $aEnzymology 606 $aPharmacology 606 $aNutrition 606 $aBioinformatics 606 $aHuman Physiology 606 $aEnzymology 606 $aPharmacology 606 $aNutrition 606 $aComputational and Systems Biology 615 0$aHuman physiology. 615 0$aEnzymology. 615 0$aPharmacology. 615 0$aNutrition. 615 0$aBioinformatics. 615 14$aHuman Physiology. 615 24$aEnzymology. 615 24$aPharmacology. 615 24$aNutrition. 615 24$aComputational and Systems Biology. 676 $a574.1925 700 $aChen$b Chang-Hwei$01062885 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910847585003321 996 $aActivation and Detoxification Enzymes$94156192 997 $aUNINA