LEADER 04207nam 2200589zu 450 001 9910137201103321 005 20230621135731.0 010 $a9782889194032 (ebook) 035 $a(CKB)3710000000526103 035 $a(SSID)ssj0001680206 035 $a(PQKBManifestationID)16496091 035 $a(PQKBTitleCode)TC0001680206 035 $a(PQKBWorkID)15028245 035 $a(PQKB)10274689 035 $a(WaSeSS)IndRDA00056161 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/52946 035 $a(oapen)doab52946 035 $a(EXLCZ)993710000000526103 100 $a20160829d2015 uy | 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aMechanisms of neural circuit formation /$fJoshua A. Weiner, Robert W. Burgess, James Jontes [editors] 210 $cFrontiers Media SA$d2015 210 31$aSwitzerland :$cFrontiers Media SA,$d2015 215 $a1 online resource (179 pages) $cillustrations; digital, PDF file(s) 225 1 $aFrontiers Research Topics 300 $aBibliographic Level Mode of Issuance: Monograph 320 $aIncludes bibliographical references. 330 $aThe formation of the proper pattern of neuronal circuits during development is critical for the normal function of the vertebrate brain and for the survival of the organism. Circuit tracing studies spanning the past 100 years have revealed the beauty and exquisite intricacy of this pattern, which represents the most complex biological system known. In humans, aberrant circuit formation is a likely underlying cause of a wide variety of birth defects and neurological disorders, including autism, intellectual disability, and schizophrenia. Furthermore, future therapeutic approaches to restoring the function of damaged neural circuits will require a better understanding of the developmental constraints under which those circuits were originally assembled. For these reasons, elucidating the molecular mechanisms of neural circuit formation is a major goal of neurobiology today.Substantial progress towards this goal has been made over the past decade, and the pace of research in the field continues to accelerate with the development of novel molecular techniques and a wider variety of genetic model systems, including zebrafish and nematodes in addition to fruit flies and mice. The aim of this Research Topic is to bring together the many strands of research that shed light on the mechanisms driving neural circuit formation: studies of the differentiation of distinct neuronal subtypes; the formation of dendritic arbors and the elaboration of postsynaptic spines; the pathfinding, targeting, and branching of axons; the proper apposition of specific pre- and post-synaptic terminals; the emerging role of glial cells in facilitating synaptogenesis and synapse elimination; and the mutations behind the aberrant circuitry that leads to neurological disorders. We seek to highlight not only newly identified molecular mechanisms, but also technical advances that have allowed progress in the field to grow exponentially, including novel imaging techniques and the proliferation of large-scale ?-omics? studies. We hope that this Research Topic will provide a forum for top researchers in the field to present new data, formulate novel hypotheses and models, and critically review recent progress in each step of neural circuit formation. 606 $aNeuroscience$2HILCC 606 $aHuman Anatomy & Physiology$2HILCC 606 $aHealth & Biological Sciences$2HILCC 610 $aneural circuit 610 $adendrite arborization 610 $aCell Adhesion Molecules 610 $aaxon guidance 610 $asynapse formation 615 7$aNeuroscience 615 7$aHuman Anatomy & Physiology 615 7$aHealth & Biological Sciences 700 $aRobert W. Burgess$4auth$01363994 702 $aBurgess$b Robert W 702 $aJontes$b James 702 $aWeiner$b Joshua A 801 0$bPQKB 801 2$bUkMaJRU 912 $a9910137201103321 996 $aMechanisms of neural circuit formation$93385065 997 $aUNINA