LEADER 04249oam 2200565 450 001 9910137100903321 005 20230621140712.0 035 $a(CKB)3710000000824693 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42565 035 $a(EXLCZ)993710000000824693 100 $a20191103h20152015 fy| 0 101 0 $aeng 135 $aurc|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe CA3 region of the hippocampus $ehow is it? what is it for? how does it do it? /$fedited by Enrico Cherubini and Richard Miles 210 $cFrontiers Media SA$d2015 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d[2015] 210 4$dİ2015 215 $a1 online resource (165 pages) $cillustrations (chiefly colour); digital file(s) 225 1 $aFrontiers Research Topics 311 08$aPrint version: The CA3 region of the hippocampus. [Lausanne, Switzerland] : Frontiers Media SA, 2015 2889196313 320 $aIncludes bibliographical references. 330 3 $aThe CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition. We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit. 410 0$aFrontiers research topics. 606 $aHippocampus (Brain) 606 $aHippocampus (Brain)$xPhysiology 606 $aNeurobiology 606 $aNeurosciences 610 $aepisodic memory 610 $amossy fibers 610 $aAssociative network 610 $aspatial representation 610 $aCA3 subfield 610 $aHippocampus 610 $aTheta Rhythm 615 0$aHippocampus (Brain) 615 0$aHippocampus (Brain)$xPhysiology. 615 0$aNeurobiology. 615 0$aNeurosciences. 676 $a612.825 700 $aEnrico Cherubini$4auth$01364363 702 $aCherubini$b Enrico 702 $aMiles$b Richard$f1951- 801 0$bUkMaJRU 906 $aBOOK 912 $a9910137100903321 996 $aThe CA3 region of the hippocampus$93385570 997 $aUNINA