LEADER 02939nam 2200421z- 450 001 9910137099803321 005 20210212 035 $a(CKB)3710000000824698 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61171 035 $a(oapen)doab61171 035 $a(EXLCZ)993710000000824698 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aTranscellular Cycles Underlying Neurotransmission 210 $cFrontiers Media SA$d2015 215 $a1 online resource (105 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-654-2 330 $aSynaptic transmission demands the operation of a highly specialized metabolic machinery involving the transfer of metabolites and neurotransmitters between neurons, astrocytes and microvessels. In the last years, important advances have occurred in our understanding of the mechanisms underlying cerebral activation, neuroglial coupling and the associated neurovascular response. Briefly, exacerbated oxygen consumption in stimulated neurons is thought to trigger glycolytic lactate and glucose transfer from astrocytes which, in turn, obtain these fuels from the microvasculature. Neurotransmitter release is made possible by a combination of transcellular cycles exchanging metabolites between these three compartments, returning eventually the synapsis to its pre-firing situation in the resting periods. In spite of the enormous progresses achieved in recent years, the drivers determining the predominant direction of the fluxes, their quantitative contribution and their energy requirements, have remained until today incompletely understood, more particularly under the circumstances prevailing in vivo. In many instances, progress derived from the implementation of novel methodological approaches including advanced neuroimaging and neurospectroscopy methods. As a consequence, literature in the field became vast, diverse and spread within journals of different specialities. The e-book "Transcellular cycles underlying neurotransmission" aims to summaryze in a single volume, recent progress achieved in hypothesis, methods and interpretations on the trafficking of metabolites between neurons and glial cells, and the associated mechanisms of neurovascular coupling. 606 $aNeurosciences$2bicssc 610 $a13C NMR 610 $aAstrocyte-neuron lactate shuttle 610 $aAstrocytic Networks 610 $afunctional MRI 610 $aglutamate-glutamine cycle 610 $aNeuroglial metabolic coupling 610 $aNeuroimaging 610 $aNeurovascular coupling 615 7$aNeurosciences 700 $aSebastian Cerdan$4auth$01328829 906 $aBOOK 912 $a9910137099803321 996 $aTranscellular Cycles Underlying Neurotransmission$93039005 997 $aUNINA