LEADER 02466nam 2200457z- 450 001 9910137099303321 005 20210211 035 $a(CKB)3710000000824700 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/54467 035 $a(oapen)doab54467 035 $a(EXLCZ)993710000000824700 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aNeural and Synaptic Defects in Autism Spectrum Disorders 210 $cFrontiers Media SA$d2015 215 $a1 online resource (285 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-628-3 330 $aAutism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology. 606 $aNeurosciences$2bicssc 610 $aAutism Spectrum Disorders 610 $aFMRP 610 $aFragile X Syndrome 610 $aMeCP2 610 $aPathogenesis 610 $aPharmacology 610 $aRett Syndrome 610 $aSynaptic deficits 610 $asynaptic plasticity 610 $aTreatment 615 7$aNeurosciences 700 $aHansen Wang$4auth$01309601 702 $aLaurie C. Doering$4auth 906 $aBOOK 912 $a9910137099303321 996 $aNeural and Synaptic Defects in Autism Spectrum Disorders$93029440 997 $aUNINA