LEADER 03461oam 2200505 450 001 9910137098703321 005 20230807212008.0 035 $a(CKB)3710000000824702 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43471 035 $a(EXLCZ)993710000000824702 100 $a20160822h20152015 fy 0 101 0 $aeng 135 $aurmn#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCognitive deficits in schizophrenia and other neuropsychiatric disorders$b[electronic resource] $econvergence of preclinical and clinical evidence /$fedited by Ales Stuchlik and Tomiki Sumiyoshi 210 $cFrontiers Media SA$d2015 210 1$aLausanne, Switzerland :$cFrontiers Media SA,$d2015. 210 4$dİ2015 215 $a1 online resource (283 pages) $cillustrations, charts; digital, PDF file(s) 225 0 $aFrontiers research topics 300 $aPublished in Frontiers in Behavioral Neuroscience. 311 $a2-88919-679-8 320 $aIncludes bibliographical references. 330 $aNeuropsychiatric disorders such as schizophrenia, extrapyramidal disorders, Alzheimer's disease and other unrelated dementias, represent a serious human, medical and socioeconomic burden. These diseases are often accompanied by impairments of cognitive function, e.g., thinking, decision-making, and learning and memory. Such deficits significantly worsen quality of life and daily functioning of afflicted patients. Cognitive deficits in schizophrenia and other psychiatric diseases are associated with alterations of brain morphology and function, which are often resistant to therapeutic interventions. In schizophrenia and related disorders, cognitive deficits are also defined as endophenotypes, measurable phenotypes linking these complex disorders with discrete heritable and reproducible traits. This points to the importance of elucidating these endophenotypes in translational studies. Experimental animal models may not mimic the full spectrum of clinical symptoms, but may work as analogies of particular behaviors or other disease manifestations. They are useful to search for the etiology of particular psychiatric illnesses and novel therapeutics. Moreover, there is accumulated evidence showing (sometimes highly specific) deficits in cognition in these animal models of neuropsychiatric disorders. Moreover, there are a series of sensitive tests to measure cognitive performance in rodents and other species. The primary focus of the present topic is to provide up-to-date information on cognitive deficits of central nervous system (CNS) disorders, and delineate future directions for translational studies aimed at developing novel treatments/interventions of these disturbances, both at clinical and preclinical levels. 606 $aNeuroscience 610 $aLearning 610 $aNeurology 610 $acognitive deficits 610 $aMemory 610 $aneuropsychiatric disorders 610 $aCognition 610 $atranslation research 610 $aanimal model 610 $aPsychiatry 615 0$aNeuroscience. 700 $aAles Stuchlik$4auth$01374730 702 $aStuchlik$b Ales 702 $aSumiyoshi$b Tomiki 801 2$bUkMaJRU 906 $aBOOK 912 $a9910137098703321 996 $aCognitive deficits in schizophrenia and other neuropsychiatric disorders$93408233 997 $aUNINA LEADER 01805nam 2200421Ka 450 001 9910695534403321 005 20070220135728.0 035 $a(CKB)5470000002371428 035 $a(OCoLC)84656093 035 $a(EXLCZ)995470000002371428 100 $a20070220d2005 ua 0 101 0 $aeng 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEffects of the implementation of resource-based practice expense relative value units under the Medicare physician fee schedule, 1998-2002$b[electronic resource] $ea study /$fconducted by the Urban Institute for the Medicare Payment Advisory Commission ; Stephanie Maxwell, Stephen Zuckerman, Pablo Aliaga 210 1$aWashington, DC :$cUrban Institute :$cMedPAC,$d[2005] 215 $a28 pages $cdigital, PDF file 225 1 $a[MedPAC contract research series] ;$vno. 05-1 300 $aTitle from title screen (viewed on Feb. 20, 2007). 300 $a"March 2005." 517 $aEffects of the implementation of resource-based practice expense relative value units under the Medicare physician fee schedule, 1998-2002 606 $aMedicare 606 $aMedical fees$zUnited States 606 $aOlder people$xMedical care$zUnited States 615 0$aMedicare. 615 0$aMedical fees 615 0$aOlder people$xMedical care 700 $aMaxwell$b Stephanie$01404574 701 $aZuckerman$b Stephen$01404575 701 $aAliaga$b Pablo$01404576 712 02$aMedicare Payment Advisory Commission (U.S.) 801 0$bGPO 801 1$bGPO 906 $aBOOK 912 $a9910695534403321 996 $aEffects of the implementation of resource-based practice expense relative value units under the Medicare physician fee schedule, 1998-2002$93479395 997 $aUNINA