LEADER 03458nam 2200457z- 450 001 9910137095903321 005 20210212 035 $a(CKB)3710000000824711 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/62741 035 $a(oapen)doab62741 035 $a(EXLCZ)993710000000824711 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aWiring Principles of Cerebral Cortex 210 $cFrontiers Media SA$d2015 215 $a1 online resource (171 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-692-5 330 $aCerebral cortex is probably the most complex biological network. Here many millions of individual neurons, the functional units of cortex, are interconnected through a massive yet highly organized pattern of axonal and dendritic wiring. This wiring enables both near and distant cells to coordinate their responses and generate a rich variety of cognitions and behaviours. When the wiring is damaged through disease or trauma it may reorganize but this may lead to characteristic pathological behaviours. While there have been significant advances in mapping cortical connectivity, the organizing principles and function of this connectivity are not well understood. On the one hand, there appears to be general design constraints governing cortical wiring, as first recognised by Ra?mon y Cajal's in his laws of conduction, material, and volume conservation. Yet on the other hand, particular patterns of cortical wiring exist to serve specific functions. There is a wide gap in understanding how the response and connectivity properties of a single neuron contribute to emergent network functions such as in detecting perceptually relevant features. Unravelling this intimate causal relationship represents one of the major challenges in neuroscience. This Research Topic will examine progress in understanding cortical wiring principles. This Research Topic aims to draw together recent advances in methods and understanding as well as recent challenges to existing ideas about how cerebral cortex is wired. This is particularly timely because new automated techniques may soon yield huge datasets in need of explanation. Recent studies have, for instance, empirically evaluated Ra?mon y Cajal's conservation laws for cerebral cortex, while others have shown some unexpected connectivity features that may refine the traditional view of how corticocortical connections are organised with regard to functional representations of auditory, somatosensory and visual cortices. Understanding these data will help improve the fidelity of neural models of cerebral cortical function and take into account the diversity of connections at both micro- and mesoscopic scales not seen at such a depth before. 606 $aNeurosciences$2bicssc 610 $aAxon 610 $abrain connectivity 610 $aBrain wiring 610 $aCerebral Cortex 610 $aconnectome 610 $aDendrite 610 $aGrey Matter 610 $amorphology 610 $anetworks 610 $asensory systems 615 7$aNeurosciences 700 $aJulian Budd$4auth$01286172 702 $aZoltan F. Kisvarday$4auth 906 $aBOOK 912 $a9910137095903321 996 $aWiring Principles of Cerebral Cortex$93019738 997 $aUNINA