LEADER 00802nam0-22002891i-450- 001 990006184330403321 005 19980601 035 $a000618433 035 $aFED01000618433 035 $a(Aleph)000618433FED01 035 $a000618433 100 $a19980601d1936----km-y0itay50------ba 105 $a--------00-yy 200 1 $a<>conventions collectives. 210 $aGeneve$cBIT$d1936 215 $aVIII,, 307 p.$d24 cm 225 1 $aÉtudes et documents$hSérie A$iVie sociale$v39 676 $a341.763 710 02$aOrganizzazione internazionale del lavoro$0411221 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990006184330403321 952 $aXXII BIT N II 39$fFGBC 959 $aFGBC 996 $aConventions collectives$9646475 997 $aUNINA DB $aGIU01 LEADER 02786nam 2200421z- 450 001 9910137094303321 005 20240229231606.0 035 $a(CKB)3710000000824720 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55828 035 $a(EXLCZ)993710000000824720 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPattern recognition receptors and cancer 210 $cFrontiers Media SA$d2015 215 $a1 electronic resource (201 p.) 225 1 $aFrontiers Research Topics 311 $a2-88919-674-7 330 $aThe group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field. 610 $aToll-Like Receptors 610 $aC-type lectin receptors 610 $anod-like receptors 610 $aDNA Repair 610 $aPattern Recognition Receptors 610 $aInflammation 610 $aRIG-I-like receptors 610 $aAutophagy 610 $aCancer 610 $aApoptosis 700 $aKutikhin$b Anton G$4auth 702 $aYuzhalin$b Arseniy E$4auth 906 $aBOOK 912 $a9910137094303321 996 $aPattern recognition receptors and cancer$93036612 997 $aUNINA