LEADER 02786nam  2200421z- 450 
001 9910137094303321
005 20240229231606.0
035   $a(CKB)3710000000824720
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55828
035   $a(EXLCZ)993710000000824720
100   $a20202102d2015      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aPattern recognition receptors and cancer
210   $cFrontiers Media SA$d2015
215   $a1 electronic resource (201 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-674-7 
330   $aThe group of pattern recognition receptors (PRRs) includes families of Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type lectin receptors (CLRs), RIG-I-like receptors (RLRs), and AIM-2-like receptors (ALRs). Conceptually, receptors constituting these families are united by two general features. Firstly, they directly recognize common antigen determinants of virtually all classes of pathogens (so-called pathogen-associated molecular patterns, or simply PAMPs) and initiate immune response against them via specific intracellular signaling pathways. Secondly, they recognize endogenous ligands (since they are usually released during cell stress, they are called damage-associated molecular patterns, DAMPs), and, hence, PRR-mediated immune response can be activated without an influence of infectious agents. So, pattern recognition receptors play the key role performing the innate and adaptive immune response. In addition, many PRRs have a number of other vital functions apart from participation in immune response realization. The fundamental character and diversity of PRR functions have led to amazingly rapid research in this field. Such investigations are very promising for medicine as immune system plays a key role in vast majority if not all human diseases, and the process of discovering the new aspects of the immune system functioning is rapidly ongoing. The role of Toll-like receptors in cancer was analyzed in certain reviews but the data are still scattered. This collection of reviews systematizes the key information in the field.
610   $aToll-Like Receptors
610   $aC-type lectin receptors
610   $anod-like receptors
610   $aDNA Repair
610   $aPattern Recognition Receptors
610   $aInflammation
610   $aRIG-I-like receptors
610   $aAutophagy
610   $aCancer
610   $aApoptosis
700   $aKutikhin$b Anton G$4auth
702   $aYuzhalin$b Arseniy E$4auth
906   $aBOOK
912   $a9910137094303321
996   $aPattern recognition receptors and cancer$93036612
997   $aUNINA