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010   $a9782889196463 (ebook)
035   $a(CKB)3710000000824732
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/45580
035   $a(EXLCZ)993710000000824732
100   $a20191103c2015uuuu  |u             |
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDynamics of cyclic nucleotide signaling in neurons$b[electronic resource] /$fedited by Pierre Vincent, Nicholas C. Spitzer
210   $cFrontiers Media SA$d2015
210  1$aFrance :$cb Frontiers Media SA,$d2015
215   $a1 online resource (92 pages) $cillustrations, charts
225 1 $aFrontiers Research Topics
320   $aIncludes bibliographical references.
330   $aCyclic nucleotides control a number of neuronal properties including neuronal differentiation, pathfinding, regulation of excitability and synaptic transmission, and control of gene expression. Signaling events mediated by cAMP or cGMP are transient and take place within the complex 3-dimensional structure of the neuronal cell. Signaling events happen on the time scale of seconds to minutes and the biological significance of the temporal dimension remains poorly understood. Structural features of neurons (dendritic spines and branches, cell body, nucleus, axon?) as well as AKAPs and other scaffolding proteins that keep signaling enzymes together and form "signaling microdomains", are critical spatial determinants of signal integration. Finally, the types of enzymes involved in signal integration, which are expressed as a number of different types and splice variants, yield another dimension that determines signal integration properties. Biosensor imaging provides direct temporal and spatial measurement of intracellular signals. This novel approach, together with more conventional methods such as biochemistry, electrophysiology, and modeling, now provide a better understanding of the spatial and temporal features of cyclic nucleotide signal integration in living neurons. This topic aims at providing a better understanding of how neurons are "making sense" of cyclic nucleotide signaling in living neurons.
606   $aNeurons
610   $arac GTP-Binding Proteins
610   $aDopamine
610   $abiosensor imaging
610   $acompartmentalization
610   $anoradrenalin
610   $aCyclic GMP
610   $aCyclic AMP
610   $aphosphodiesterases
610   $aEndocannabinoids
615  0$aNeurons
700   $aNicholas C. Spitzer$4auth$01367187
702   $aVincent$b Pierre
702   $aSpitzer$b Nicholas C.
801  0$bUkMaJRU
912   $a9910137092203321
996   $aDynamics of cyclic nucleotide signaling in neurons$93389917
997   $aUNINA