LEADER 03890nam 2200517 450 001 9910137091903321 005 20230807212005.0 035 $a(CKB)3710000000824734 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43190 035 $a(EXLCZ)993710000000824734 100 $a20160822h20152015 fu 0 101 0 $aeng 135 $aurm|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aChronic inflammation in conditions associated with a deficient clearance of dying and dead cells, their remnants, and intracellular constituents$b[electronic resource] /$fedited by Luis Enrique Muñoz, Christian Berens, Kirsten Lauber [and 2 others] 210 $cFrontiers Media SA$d2015 210 1$aLausanne, Switzerland :$cFrontiers Media SA,$d[2015]. 210 4$d©2015 215 $a1 online resource (73 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers research topics 300 $aPublished in Frontiers in Immunology. 311 $a2-88919-601-1 320 $aIncludes bibliographical references. 330 $aIn multicellular organisms, states with a high degree of tissue turnover like embryogenesis, development, and adult tissue homeostasis need an instantaneous, tightly regulated and immunologically silent clearance of these dying cells to ensure appropriate development of the embryo and adult tissue remodelling. The proper and swift clearance of apoptotic cells is essential to prevent cellular leakage of damage associated molecular patterns (DAMPs) which would lead to the stimulation of inflammatory cytokine responses. In addition to the clearance of apoptotic cells (efferocytosis), backup mechanisms are required to cope with DAMPs (HMGB-1, DNA, RNA, S100 molecules, ATP and adenosine) and other intracellular material (uric acid, intracellular proteins and their aggregates) released from cells, that were not properly cleared and have entered the stage of secondary necrosis. Furthermore, under certain pathologic conditions (e.g. gout, cancer, diabetes) non-apoptotic cell death may transiently occur (NETosis, necroptosis, pyroptosis) which generates material that also has to be cleared to avoid overloading tissues with non-functional cellular waste. Efficient efferocytosis is therefore indispensable for normal tissue turnover and homeostasis. The characterization of various signalling pathways that regulate this complex and evolutionary conserved process has shed light on new pathogenetic mechanisms of many diseases. Impaired clearance promotes initiation of autoimmunity as well as the perpetuation of chronic inflammation, but may also foster anti-tumor immunity under certain microenvironmental conditions. Immunological tolerance is continuously being challenged by the presence of post-apoptotic remnants in peripheral lymphoid tissues. Besides the autoimmune phenotype of chronic inflammatory rheumatoid disorders a plethora of pathologies have been associated with defects in genes involved in clearance, e.g. atherosclerosis, cancer, gout, diabetes, some forms of blindness, neuropathy, schizophrenia and Alzheimer?s disease. 606 $aImmunology 610 $aAutoimmunity 610 $aNETs 610 $aEfferocytosis 610 $aInflammation 610 $acell-remnants 610 $aPhagocytosis 610 $aApoptosis 610 $aCancer 610 $aAsthma 615 0$aImmunology. 700 $aMartin Herrmann$4auth$01376288 702 $aMuñoz$b Luis Enrique 702 $aBerens$b Christian 702 $aLauber$b Kirsten 801 2$bUkMaJRU 906 $aBOOK 912 $a9910137091903321 996 $aChronic inflammation in conditions associated with a deficient clearance of dying and dead cells, their remnants, and intracellular constituents$93411846 997 $aUNINA