LEADER 03890nam 2200517 450 001 9910137091903321 005 20230807212005.0 035 $a(CKB)3710000000824734 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43190 035 $a(EXLCZ)993710000000824734 100 $a20160822h20152015 fu 0 101 0 $aeng 135 $aurm|#---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aChronic inflammation in conditions associated with a deficient clearance of dying and dead cells, their remnants, and intracellular constituents$b[electronic resource] /$fedited by Luis Enrique Muñoz, Christian Berens, Kirsten Lauber [and 2 others] 210 $cFrontiers Media SA$d2015 210 1$aLausanne, Switzerland :$cFrontiers Media SA,$d[2015]. 210 4$d©2015 215 $a1 online resource (73 pages) $cillustrations; digital, PDF file(s) 225 0 $aFrontiers research topics 300 $aPublished in Frontiers in Immunology. 311 $a2-88919-601-1 320 $aIncludes bibliographical references. 330 $aIn multicellular organisms, states with a high degree of tissue turnover like embryogenesis, development, and adult tissue homeostasis need an instantaneous, tightly regulated and immunologically silent clearance of these dying cells to ensure appropriate development of the embryo and adult tissue remodelling. The proper and swift clearance of apoptotic cells is essential to prevent cellular leakage of damage associated molecular patterns (DAMPs) which would lead to the stimulation of inflammatory cytokine responses. In addition to the clearance of apoptotic cells (efferocytosis), backup mechanisms are required to cope with DAMPs (HMGB-1, DNA, RNA, S100 molecules, ATP and adenosine) and other intracellular material (uric acid, intracellular proteins and their aggregates) released from cells, that were not properly cleared and have entered the stage of secondary necrosis. Furthermore, under certain pathologic conditions (e.g. gout, cancer, diabetes) non-apoptotic cell death may transiently occur (NETosis, necroptosis, pyroptosis) which generates material that also has to be cleared to avoid overloading tissues with non-functional cellular waste. Efficient efferocytosis is therefore indispensable for normal tissue turnover and homeostasis. The characterization of various signalling pathways that regulate this complex and evolutionary conserved process has shed light on new pathogenetic mechanisms of many diseases. Impaired clearance promotes initiation of autoimmunity as well as the perpetuation of chronic inflammation, but may also foster anti-tumor immunity under certain microenvironmental conditions. Immunological tolerance is continuously being challenged by the presence of post-apoptotic remnants in peripheral lymphoid tissues. Besides the autoimmune phenotype of chronic inflammatory rheumatoid disorders a plethora of pathologies have been associated with defects in genes involved in clearance, e.g. atherosclerosis, cancer, gout, diabetes, some forms of blindness, neuropathy, schizophrenia and Alzheimer?s disease. 606 $aImmunology 610 $aAutoimmunity 610 $aNETs 610 $aEfferocytosis 610 $aInflammation 610 $acell-remnants 610 $aPhagocytosis 610 $aApoptosis 610 $aCancer 610 $aAsthma 615 0$aImmunology. 700 $aMartin Herrmann$4auth$01376288 702 $aMuñoz$b Luis Enrique 702 $aBerens$b Christian 702 $aLauber$b Kirsten 801 2$bUkMaJRU 906 $aBOOK 912 $a9910137091903321 996 $aChronic inflammation in conditions associated with a deficient clearance of dying and dead cells, their remnants, and intracellular constituents$93411846 997 $aUNINA LEADER 02263oas 2200769 a 450 001 9910143757103321 005 20251105213014.0 011 $a1943-6351 035 $a(OCoLC)74812195 035 $a(CONSER) 2006231389 035 $a(CKB)991042724318176 035 $a(EXLCZ)99991042724318176 100 $a20061101b19812005 sa a 101 0 $aeng 135 $auran||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aWater resources data$iWashington 210 $aTacoma, Wash. $cU.S. Dept. of the Interior, U.S. Geological Survey$d-2006 215 $a1 online resource 225 1 $aWater-data report 311 08$a0364-3557 410 0$aU.S. Geological Survey water-data report. 517 3 $aWashington 531 0 $aWater resour. data Wash. 606 $aWater-supply$zWashington (State)$vStatistics$vPeriodicals 606 $aStream measurements$zWashington (State)$vStatistics$vPeriodicals 606 $aWater quality$zWashington (State)$vStatistics$vPeriodicals 606 $aStream measurements$2fast$3(OCoLC)fst01134581 606 $aWater quality$2fast$3(OCoLC)fst01171832 606 $aWater-supply$2fast$3(OCoLC)fst01172350 607 $aWashington (State)$2fast$1https://id.oclc.org/worldcat/entity/E39PBJpymmTY6j9pxXGMd79FKd 608 $aPeriodicals.$2fast 608 $aStatistics.$2fast 608 $aStatistics.$2lcgft 608 $aPeriodicals.$2lcgft 615 0$aWater-supply 615 0$aStream measurements 615 0$aWater quality 615 7$aStream measurements. 615 7$aWater quality. 615 7$aWater-supply. 676 $a553 712 02$aGeological Survey (U.S.) 712 02$aWashington Water Science Center (Geological Survey) 801 0$bGPO 801 1$bGPO 801 2$bGPO 801 2$bDLC 801 2$bNSD 801 2$bOCLCQ 801 2$bOCLCE 801 2$bGPO 801 2$bOCLCQ 801 2$bOCLCF 801 2$bOCLCA 801 2$bOCLCQ 801 2$bGILDS 801 2$bOCLCO 801 2$bOCLCQ 801 2$bOCLCL 801 2$bOCLCQ 906 $aJOURNAL 912 $a9910143757103321 996 $aWater resources data$91982357 997 $aUNINA LEADER 05476nam 22009735 450 001 9910624356703321 005 20260330164142.0 010 $a9783839462294 010 $a3839462290 024 7 $a10.1515/9783839462294 035 $a(CKB)5580000000395348 035 $a(DE-B1597)626040 035 $a(DE-B1597)9783839462294 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/93925 035 $a(OCoLC)1349351499 035 $a(MiAaPQ)EBC30469294 035 $a(Au-PeEL)EBL30469294 035 $a(MiAaPQ)EBC7111900 035 $a(ScCtBLL)4f71f199-5961-4865-8e1b-7981efb89d57 035 $a(oapen)doab93925 035 $a(EXLCZ)995580000000395348 100 $a20221107h20222022 fg 101 0 $ager 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aEthik für die Geographiedidaktik $eOrientierungen in Forschung und Praxis /$fhrsg. von Jochen Laub, Georg Gudat, Mirka Dickel 205 $a1st ed. 210 $aBielefeld$ctranscript Verlag$d2022 210 1$aBielefeld :$ctranscript Verlag,$d[2022] 210 4$d©2022 215 $a1 online resource (276 p.) 225 0 $aSozial- und Kulturgeographie ;$v58 311 08$a9783837662290 311 08$a3837662292 327 $tFrontmatter --$tInhalt --$tEthik und Geographiedidaktik ? Perspektiven, Zugänge, Variationen --$tEthische Orientierung geographiedidaktischer Praxis --$tDer moralische Impuls im Geographieunterricht --$tBereichsethisches Wissen im Geographieunterricht vermitteln? --$tEthische Urteilskompetenz im Geographieunterricht --$tNachhaltigkeit und Ethisches Lernen im Kontext einer lösungsorientierten Didaktik --$tMit Aufgaben Reflexionsanlässe schaffen, damit Lernende Werthaltungen entwickeln können --$tGeographiedidaktische Forschung als ethische Praxis --$tEine Schulbuchanalyse zu BNE-bezogenen Aufgabenstellungen zum Kompetenzbereich Handlung im Geographieunterricht --$tEthisches Handeln im Raum aus der Perspektive praxistheoretischer Ansätze --$tKann es denn eine auf die Geographiedidaktik begrenzte Ethik geben? --$tNaturbeziehungen im Spiegel der Anderen --$tVorbildlich unterrichten. Mimesis und geographiedidaktisches Ethos --$tAutorinnen- und Autorenverzeichnis 330 $aEthische Grundfragen erlangen in der geographiedidaktischen Forschungs- und Vermittlungspraxis zunehmend an Bedeutung. Dabei setzt sich werthaltige Didaktik nicht nur auf der unterrichtspraktischen Ebene in Szene, sondern auch auf der fachdidaktischen. Die Beiträger*innen des Bandes versammeln verschiedene Perspektiven auf ethische und moralische Fragestellungen, die sich im Kontext der Geographiedidaktik zeigen. Der Grundfrage folgend, wie Bildungsprozesse im Fach verantwortungsvoll gestaltet und ethisch begründet werden können, fokussieren sie u.a. die Themen Wissenschaftsethik, Professionalisierungsforschung, Kompetenzorientierung, Bildung für nachhaltige Entwicklung und Globalisierung. 410 0$aSozial- und Kulturgeographie Series 606 $aSOCIAL SCIENCE / Human Geography$2bisacsh 610 $aClassroom Practices. 610 $aCompetency. 610 $aCultural Geography. 610 $aDidactics. 610 $aEducation. 610 $aEducational Research. 610 $aGeography. 610 $aJudgement. 610 $aProfessionalisation. 610 $aResponsibility. 610 $aSchool. 610 $aSocial Geography. 610 $aSpace. 610 $aSustainability. 610 $aTeaching. 610 $aUniversity. 615 7$aSOCIAL SCIENCE / Human Geography. 686 $aRB 10853$qSEPA$2rvk 700 $aDickel$b Mirka$4edt$01427637 702 $aApplis$b Stefan$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aBarth$b Marcel$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aDickel$b Mirka$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aDickel$b Mirka$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aFelzmann$b Dirk$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aGhafoor-Zadeh$b Dana$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aGudat$b Georg$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aGudat$b Georg$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKuckuck$b Miriam$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aLaub$b Jochen$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aLaub$b Jochen$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLindau$b Anne-Kathrin$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aMehren$b Rainer$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aMu?ller$b Michael$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aSchneider$b Antje$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aSchreiber$b Verena$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aUlrich-Riedhammer$b Eva Marie$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aVielhaber$b Christian$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 702 $aWeiss$b Gu?nther$f1962-$4ctb$4https://id.loc.gov/vocabulary/relators/ctb 801 0$bDE-B1597 801 1$bDE-B1597 906 $aBOOK 912 $a9910624356703321 996 $aEthik für die Geographiedidaktik$93562054 997 $aUNINA