LEADER 00949nam0-2200253 --450 001 9910591300903321 005 20220921100113.0 100 $a20220921d1958----kmuy0itay5050 ba 101 1 $ager 102 $aDE 105 $a 001yy 200 1 $a<>naturliche Entscheidungsrecht des Mannes in Ehe und Familie$eein Beitrag zur Frage der Gleichberechtigung von Mann und Frau 210 $aHeidelberg$cKerle$aLowen$cNauwelaerts$d1958 215 $aXXVIII, 508 p.$d24 cm. 225 1 $aSammlung politeia$fVeroffentlichungen des Internationalen Instituts fur Sozialwissenschaft und Politik Universitat Freiburg/Schweiz ...$v11 676 $a340$zger 700 1$aZiegler,$bAlbert$01202790 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910591300903321 952 $aUniversità 136 (11)$b55397$fFGBC 959 $aFGBC 996 $aNaturliche Entscheidungsrecht des Mannes in Ehe und Familie$92910855 997 $aUNINA LEADER 03605nam 2200469z- 450 001 9910137090303321 005 20251201194000.0 010 $a9782889196166 (ebook) 035 $a(CKB)3710000000824743 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43103 035 $a(oapen)doab43103 035 $a(EXLCZ)993710000000824743 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aChemokines and chemokine receptors in brain homeostasis 210 $cFrontiers Media SA$d2015 210 1$aFrance :$cFrontiers Media SA,$d2015 215 $a1 online resource (124 p.) 225 1 $aFrontiers Research Topics 320 $aIncludes bibliogrpahical references. 330 $aVirtually involved in all pathologies that present an inflammatory component, it is now evident that, in the central nervous system, chemokines and chemokine receptors possess pleiotropic properties beyond chemotaxis: costitutive brain expression of chemokines and their receptors on endothelial cells, but also on neurons and glia, suggests a role for such molecules in mediating homeostatic cross-talk between cells of the brain perenchyma. Cross-talk between neurons and glia is determinant to the establishment and maintenance of a brain environment that ensure normal function, and in particular glial cells are active players that respond to environmental changes and act for the survival, growth, differentiation and repair of the nervous tissue: in this regard brain endogenous chemokines represent key molecules that play a role in brain development, neurogenesis, neurotransmission and neuroprotection. As important regulators of peripheral immune response, chemokines are molecules of the immune system that play a central role in coordinating communication between the nervous and the immune systems, in the context of infections and brain injury. Indeed, in phatological processes resulting from infections, brain trauma, ischemia and chronic neurodegenerative diseases, chemokines represent important neuroinflammatory mediators that drive leucocytes trafficking into the central nervous system, facilitating an immune response by targeting cells of the innate and adaptive immune system. The third edition of the international conference "Chemokines and Chemokine Receptors in the Nervous System", hold in Rome in October 2013, represented an exciting platform to promote discussion among researchers in different disciplines to understand the role of chemokines in brain homoestasis. This Frontiers Research Topic arises from this conference, and wants to be an opportunity to further discuss and highlight the importance of brain chemokines as key molecules that, not only grant the interplay between the immune and the nervous systems, but in addition drive modulatory functions on brain homeoastasis orchestrating neurons, microglia, and astrocytes communication. 606 $aNeurosciences$2bicssc 610 $aBrain homeostasis 610 $abrain pathology 610 $aChemokine receptors 610 $aChemokines 610 $aGlioblastoma 610 $aInflammation 610 $aneurons-glia cross-talk 610 $aneurotransmission 610 $aPain 615 7$aNeurosciences 700 $aRichard M. Ransohoff$4auth$01300249 702 $aFlavia Trettel$4auth 801 0$bUkMaJRU 912 $a9910137090303321 996 $aChemokines and chemokine receptors in brain homeostasis$93025490 997 $aUNINA