LEADER 03818nam 22006015 450 001 9910674353103321 005 20230810181013.0 010 $a3-031-23592-4 024 7 $a10.1007/978-3-031-23592-4 035 $a(MiAaPQ)EBC7205364 035 $a(Au-PeEL)EBL7205364 035 $a(CKB)26170318100041 035 $a(DE-He213)978-3-031-23592-4 035 $a(PPN)268205167 035 $a(EXLCZ)9926170318100041 100 $a20230223d2023 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aStructural Engineering $eModels and Methods for Statics, Instability and Inelasticity /$fby Adnan Ibrahimbegovic, Rosa-Adela Mejia-Nava 205 $a1st ed. 2023. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2023. 215 $a1 online resource (542 pages) 225 1 $aLecture Notes in Applied and Computational Mechanics,$x1860-0816 ;$v100 311 08$aPrint version: Ibrahimbegovic, Adnan Structural Engineering Cham : Springer International Publishing AG,c2023 9783031235917 327 $aIntroduction -- Truss Model: General Theorems and Methods of Force, Displacement and Finite Elements -- Beam Models: Refinement and Reduction -- Plate Models: Validation and Verification -- Solids, Membranes and Shells with Drilling Rotations: Complex Structures -- Large Displacements and Instability: Buckling vs. Nonlinear Instability -- Inelasticity: Ultimate Load and Localized Failure -- Brief on Mulitscale, Dynamics and Probability -- References. 330 $aThis book presents a novel approach to the classical scientific discipline of Structural Engineering, which is inspired by numerous current applications from domains of Civil, Mechanical or Aerospace Engineering. The main goal of this book is to help with making the best choice between accuracy and efficiency, when it comes to building the most suitable structural models by practising engineers using modern computational tools available in commercial software products (SAP, FEAP, ANSYS ?) for which we have carried out many developments that have been become the main reference in the field. Any development of this kind is not a mere modification of discrete approximation, but a thorough treatment with a sound theoretical formulation based upon Hu-Washizu variational principle with independent rotation field, its corresponding regularization and finally the most appropriate finite element interpolation that can match those used for structural elements. Proposed approach allows us to provide a unified discrete approximation of complex structural assemblies and greatly simplify the modeling task for structural engineers. Thus, in conclusion, this book can also be perceived as the theoretical manual for using modern computer models successfully by practising engineers. 410 0$aLecture Notes in Applied and Computational Mechanics,$x1860-0816 ;$v100 606 $aMechanics, Applied 606 $aMathematics$xData processing 606 $aBuilding materials 606 $aEngineering Mechanics 606 $aComputational Mathematics and Numerical Analysis 606 $aStructural Materials 615 0$aMechanics, Applied. 615 0$aMathematics$xData processing. 615 0$aBuilding materials. 615 14$aEngineering Mechanics. 615 24$aComputational Mathematics and Numerical Analysis. 615 24$aStructural Materials. 676 $a624.1 676 $a624.171 700 $aIbrahimbegovic?$b Adnan$01188978 702 $aMejia-Nava$b Rosa-Adela 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910674353103321 996 $aStructural Engineering$93056946 997 $aUNINA LEADER 02811nam 2200457z- 450 001 9910137089803321 005 20210212 035 $a(CKB)3710000000824746 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57181 035 $a(oapen)doab57181 035 $a(EXLCZ)993710000000824746 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPromiscuous functions of the prion protein gene family 210 $cFrontiers Media SA$d2015 215 $a1 online resource (113 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-605-4 330 $aThe cellular prion protein PrPC is a ubiquitous GPI-anchored protein. While PrPC has been the focus of intense research for its involvement in a group of neurodegenerative disorders known as transmissible spongiform encephalopathies (TSE), much less attention has been devoted to its physiological function. This notably relates to the lack of obvious abnormalities of mice, goat or cattle lacking PrPC. This apparently normal phenotype in these PrPC-deficient animals however contrasts with the very high degree of conservation of the prion protein gene (Prnp) in mammalian species (over 80%), and the presence of genes with similarities to Prnp in birds, reptiles, amphibians and fish. This high conservation together with its ubiquitous expression, - albeit at highest levels in the brain-, suggest that PrPC has major physiological functions. Dissecting PrPC function is further complicated by the occurrence, in mammals, of two potentially partially redundant homologues, Doppel, and Shadoo. The biological overlaps between members of the prion protein family are still under investigation and much debated. Similarly, although in vitro analyses have suggested various functions for PrPC, notably in cell death and survival processes, some have yielded conflicting results and/or discrepancies with in vivo studies. This Research Topic brings together the accumulated knowledge regarding the biological roles of the prion protein family, from the animal to the molecular scale. 606 $aBiology, life sciences$2bicssc 610 $aabeta 610 $aAging 610 $aCell Adhesion 610 $aCell signaling 610 $aEmbryonic and Fetal Development 610 $aGonads 610 $aNeuroprotection 610 $aPlacenta 610 $aprion protein 610 $aStem Cells 615 7$aBiology, life sciences 700 $aJean-Luc Vilotte$4auth$01286170 702 $aSophie Mouillet-Richard$4auth 906 $aBOOK 912 $a9910137089803321 996 $aPromiscuous functions of the prion protein gene family$93019736 997 $aUNINA