LEADER 02708nam 2200421z- 450 001 9910137089803321 005 20231214133050.0 035 $a(CKB)3710000000824746 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57181 035 $a(EXLCZ)993710000000824746 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPromiscuous functions of the prion protein gene family 210 $cFrontiers Media SA$d2015 215 $a1 electronic resource (113 p.) 225 1 $aFrontiers Research Topics 311 $a2-88919-605-4 330 $aThe cellular prion protein PrPC is a ubiquitous GPI-anchored protein. While PrPC has been the focus of intense research for its involvement in a group of neurodegenerative disorders known as transmissible spongiform encephalopathies (TSE), much less attention has been devoted to its physiological function. This notably relates to the lack of obvious abnormalities of mice, goat or cattle lacking PrPC. This apparently normal phenotype in these PrPC-deficient animals however contrasts with the very high degree of conservation of the prion protein gene (Prnp) in mammalian species (over 80%), and the presence of genes with similarities to Prnp in birds, reptiles, amphibians and fish. This high conservation together with its ubiquitous expression, - albeit at highest levels in the brain-, suggest that PrPC has major physiological functions. Dissecting PrPC function is further complicated by the occurrence, in mammals, of two potentially partially redundant homologues, Doppel, and Shadoo. The biological overlaps between members of the prion protein family are still under investigation and much debated. Similarly, although in vitro analyses have suggested various functions for PrPC, notably in cell death and survival processes, some have yielded conflicting results and/or discrepancies with in vivo studies. This Research Topic brings together the accumulated knowledge regarding the biological roles of the prion protein family, from the animal to the molecular scale. 610 $aStem Cells 610 $aNeuroprotection 610 $aPlacenta 610 $aabeta 610 $aAging 610 $aEmbryonic and Fetal Development 610 $aCell Adhesion 610 $aGonads 610 $aCell signaling 610 $aprion protein 700 $aJean-Luc Vilotte$4auth$01286170 702 $aSophie Mouillet-Richard$4auth 906 $aBOOK 912 $a9910137089803321 996 $aPromiscuous functions of the prion protein gene family$93019736 997 $aUNINA