LEADER 03736nam 2200445z- 450 001 9910137088903321 005 20210212 035 $a(CKB)3710000000824751 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57569 035 $a(oapen)doab57569 035 $a(EXLCZ)993710000000824751 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRadiation-induced and oxidative DNA damages 210 $cFrontiers Media SA$d2015 215 $a1 online resource (93 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-660-7 330 $aDNA stores and passes the genetic information of almost all living organisms. Its molecular structure and their intramolecular interactions are particularly suitable to maximize stability against oxidative stress and UV-light absorption. Yet the protection and repair strategies are still error-prone: DNA lesions are produced, including the most complex and highly mutagenic ones. An important threat to DNA stability comes from photosensitization, i.e. from the dramatic multiplication of radiation-induced defects mediated by the presence of organic or organometallic dyes compared to the direct exposure to UVA radiation. Moreover, the photo-induced production of singlet oxygen generates an extremely high oxidative stress on DNA that, in vivo, normally results in extended cellular apoptosis. Elucidating the processes leading to DNA damages, from the production of a simple radical entity to deleterious lesions, as well as the opportunities of repair by devoted enzymes, is a cornerstone towards the development of more efficient protection strategies. Sensitization and selective production of DNA lesions can also be exploited to induce the selective apoptosis of cancer cells upon exposition to radiation or to oxidative stress, for instance in the field of photodynamic therapy. The importance and relevance of the field is witnessed by the impressive amount of high-level papers dealing with this complex subject, and notably tackling the structural elucidation of DNA and DNA-drug adducts, the mechanisms of formation of DNA lesions (including the precise detection of the final lesion products), as well as the influence of the lesions on the DNA stability and dynamics and the consequences on the ease of repair. Due to the complexity of the field lying at the frontiers between chemistry, physics and biology, multidisciplinary strategies allying modeling and experience are needed. This topic aims at giving an extended overview of the current research in the domain, with fundamental contribution from the leading groups in the field of DNA reactivity, structural characterization, photo-chemistry and photo-physics, as well as repair mechanism. It will therefore be a fundamental guide for scientists wanting to address the field of DNA lesion and repair, but also more generally for researchers working in rational drug design or in the development of biomarkers and medical imaging techniques. 606 $aChemistry$2bicssc 610 $aAnalytical Chemistry 610 $aDNA lesions 610 $aOxidative damages 610 $aPhotochemistry and Photophysics 610 $aPhotosensitization 610 $aRadiation induced lesions 610 $asimulation and modeling 610 $aspectroscopy 615 7$aChemistry 700 $aElise Dumont$4auth$01305911 702 $aAntonio Monari$4auth 702 $aChryssostomos Chatgilialoglu$4auth 906 $aBOOK 912 $a9910137088903321 996 $aRadiation-induced and oxidative DNA damages$93028008 997 $aUNINA