LEADER 05100nam 2200637 450 001 9910814841103321 005 20200514202323.0 010 $a1-4742-4180-8 010 $a1-4742-4182-4 010 $a1-4742-4181-6 024 7 $a10.5040/9781474241823 035 $a$b-949tlc9155563mu_inst 035 $a(CKB)3840000000339111 035 $a(OCoLC)1019900773 035 $a(MiAaPQ)EBC5226711 035 $a(CaBNVSL)9781474241823 035 $a(EXLCZ)993840000000339111 100 $a20190429e20192018 uy 0 101 0 $aeng 135 $aur|n||||||||| 181 $ctxt$2rdacontent 182 $cn$2rdamedia 183 $anc$2rdacarrier 200 00$aDesign roots $eculturally significant designs, products, and practices /$fedited by Stuart Walker, Martyn Evans, Tom Cassidy, Jeyon Jung, and Amy Twigger Holroyd 205 $aFirst edition. 210 1$aLondon, England :$cBloomsbury Publishing,$d2018. 215 $axix, 378 $cillustrations, maps ;$d25 cm 311 $a1-350-10341-1 311 $a1-4742-4179-4 320 $aIncludes bibliographical references and index. 327 $aPart I: Culturally significant designs, products, and practices. Editorial introduction -- Martyn Evans -- 1. Creative ecologies -- Jeyon Jung and Stuart Walker -- 2. Forging new futures -- Amy Twigger Holroyd -- 3. Culturally significant artifacts and their relationship to traditional sustainability -- Stuart Walker -- 4. Making and its cultural ecological foundations -- Patrick Dillon -- Part II. Authenticity and tradition in material culture. Editorial introduction -- Amy Twigger Holroyd -- The Aran jumper -- Siun Carden -- Chok weaving and textile enterprises -- Disaya Chudasri -- Oltu-stone prayer beads -- Hazal Gumus Ciftci -- The Mi?an-Sar?a -- Poone Yazdanpanah and Stuart Walker-- IKEA -- Sara Kristoffersson -- Part III: Revitalization by design. Editorial introduction -- Tom Cassidy -- 10. Culture as a resource for a sustainable future in indigenous communities -- Anne Marchand, Karine Awashish, Christian Coocoo, Solen Roth, Renata Marques Leitao, Cedric Sportes, and Caoimhe Isha Beaule -- 11.Transforming tradition in Indonesia -- Adhi Nugraba -- 12. New translations of South Korean patterns -- Meong Jin Shin -- 13. Revitalization by design -- Sebastian Cox -- 14. New Caribbean design -- Patty Johnson -- Part IV: Enterprise, policy and education for positive development. Editorial introduction -- Jeyon Jung -- 15. Sustaining culturally significant designs, products and practices -- Jacques Giard -- 16. Accidents, intentions, movements, and makers -- Steve Marotta, Austin Cummings, and Charles Heying -- 17. The role of higher education in sustaining culturally significant crafts in Estonia -- Sirpa Kokko -- 18. The challenge of intellectual property rights for culturally significant patterns, products, and processes -- Tom Cassidy and Tracy Diane Cassidy -- 19. The case of the city different -- Marsha C. Bol -- Part V: Design futures. Editorial introduction -- Stuart Walker and Martyn Evans. -- 20. Research approaches for culturally significant design -- Tom Cassidy -- 330 $a"Design Roots provides a comprehensive review of culturally significant designs, products and practices which are rooted to particular communities through making tradition and a sense of place. This book considers the creative roots, the place-based ecologies, and deep understandings of cultural significance, not only in terms of history and tradition but also in terms of locale, social interactions, innovation, and change for the sustainment of culturally significant material productions. Contributing authors explore the historical roots of culturally significant designs, products and practices, emerging directions, amateur endeavours, enterprise models, business opportunities and the changing role and contribution of design in the creation of material cultures of significance, meaning and value. An international perspective is provided through case studies and research from North and South America, Africa, Europe, Asia and Australasia, with examples including Aran jumper production in Northern Ireland, weaving in Thailand, Iranian housing design, Brazilian street design and digital crafting in the United Kingdom."--$cProvided by publisher. 606 $aDecoration and ornament 606 $aMaterial culture 606 $aProduct design 606 $2Product design 610 0$aDesign Research and Futures 610 0$aHistory and Culture of Design 610 0$aMaterial Culture 610 0$aProduct Design 615 0$aDecoration and ornament. 615 0$aMaterial culture. 615 0$aProduct design. 676 $a745.409 702 $aCassidy$b Tom$cProfessor of design, 702 $aEvans$b M$g(Martyn), 702 $aHolroyd$b Amy Twigger 702 $aJung$b J$g(Jeyon), 702 $aWalker$b Stuart$f1955- 801 0$bNZAUC 801 1$bCaBNVSL 801 2$bUkLoBP 906 $aBOOK 912 $a9910814841103321 996 $aDesign roots$92602512 997 $aUNINA LEADER 03736nam 2200445z- 450 001 9910137088903321 005 20210212 035 $a(CKB)3710000000824751 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/57569 035 $a(oapen)doab57569 035 $a(EXLCZ)993710000000824751 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRadiation-induced and oxidative DNA damages 210 $cFrontiers Media SA$d2015 215 $a1 online resource (93 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-660-7 330 $aDNA stores and passes the genetic information of almost all living organisms. Its molecular structure and their intramolecular interactions are particularly suitable to maximize stability against oxidative stress and UV-light absorption. Yet the protection and repair strategies are still error-prone: DNA lesions are produced, including the most complex and highly mutagenic ones. An important threat to DNA stability comes from photosensitization, i.e. from the dramatic multiplication of radiation-induced defects mediated by the presence of organic or organometallic dyes compared to the direct exposure to UVA radiation. Moreover, the photo-induced production of singlet oxygen generates an extremely high oxidative stress on DNA that, in vivo, normally results in extended cellular apoptosis. Elucidating the processes leading to DNA damages, from the production of a simple radical entity to deleterious lesions, as well as the opportunities of repair by devoted enzymes, is a cornerstone towards the development of more efficient protection strategies. Sensitization and selective production of DNA lesions can also be exploited to induce the selective apoptosis of cancer cells upon exposition to radiation or to oxidative stress, for instance in the field of photodynamic therapy. The importance and relevance of the field is witnessed by the impressive amount of high-level papers dealing with this complex subject, and notably tackling the structural elucidation of DNA and DNA-drug adducts, the mechanisms of formation of DNA lesions (including the precise detection of the final lesion products), as well as the influence of the lesions on the DNA stability and dynamics and the consequences on the ease of repair. Due to the complexity of the field lying at the frontiers between chemistry, physics and biology, multidisciplinary strategies allying modeling and experience are needed. This topic aims at giving an extended overview of the current research in the domain, with fundamental contribution from the leading groups in the field of DNA reactivity, structural characterization, photo-chemistry and photo-physics, as well as repair mechanism. It will therefore be a fundamental guide for scientists wanting to address the field of DNA lesion and repair, but also more generally for researchers working in rational drug design or in the development of biomarkers and medical imaging techniques. 606 $aChemistry$2bicssc 610 $aAnalytical Chemistry 610 $aDNA lesions 610 $aOxidative damages 610 $aPhotochemistry and Photophysics 610 $aPhotosensitization 610 $aRadiation induced lesions 610 $asimulation and modeling 610 $aspectroscopy 615 7$aChemistry 700 $aElise Dumont$4auth$01305911 702 $aAntonio Monari$4auth 702 $aChryssostomos Chatgilialoglu$4auth 906 $aBOOK 912 $a9910137088903321 996 $aRadiation-induced and oxidative DNA damages$93028008 997 $aUNINA