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010   $a9782889196449
035   $a(CKB)3710000000824754
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/40472
035   $a(EXLCZ)993710000000824754
100   $a20191103h20152015  fy|            0
101 0 $aeng
135   $aurcn#---||||n
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAging, neurogenesis and neuroinflammation in hearing loss and protection /$fMarta Magariños, Marta Milo and Isabel Varela-Nieto
210   $cFrontiers Media SA$d2015
210  1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d[2015]
210  4$d©2015
215   $a1 online resource (151 pages) $cillustrations (chiefly colour); digital file(s)
225 1 $aFrontiers Research Topics
311 08$aPrint version: 2889196445 
320   $aIncludes bibliographical references.
330 3 $aWorldwide, 278 million people are estimated to have moderate to profound hearing loss. Age-related hearing loss, also known as presbyacusis, affects approximately half of the population over 60 years old, making it the second most common cause of disability in older people. Hearing loss occurs when the sensory cells and neurons of the cochlea degenerate and die. The vestibular system, which holds the sense of balance, shares a common embryonic origin with the cochlea and together conform the inner ear. Balance problems are a trait of ageing to the point that balance ability is considered a sensor of physical decline and vestibular degeneration is the most common cause of falls in the elderly. Still the molecular bases of ageing in the vestibular system have not been studied in detail. Genetic and environmental factors contribute to the progression of age-related hearing loss (ARHL). Being noise the main environmental noxious agent for human hearing in the industrialized societies.There is no restorative treatment for deafness but functional replacement by means of prosthesis. Therefore, prevention and treatment of hearing loss is an unmet medical need. To develop innovative medical strategies against hearing loss, it is critical to understand the causes of ARHL and the essential pathways responsible for the manifestation of this complex disease.In this research topic, experts will discuss the stages and molecular elements of the damage and repair processes involved in ARHL, from cellular processes involved in ageing as senescence and autophagy, to molecules essential for hearing as IGF-1 and neurotrophins. Neuroinflammation takes a central stage as an essential element in the progression of injury and cell loss, and a target for cell protection strategies. Neurogenesis is also essential to understand the adult cochlea self-repair potential. Finally, the mechanisms of action and the potential of novel therapies for hair cell repair and protection will be discussed along with drug delivery strategies.
410  0$aFrontiers research topics.
606   $aPresbycusis
606   $aVestibular apparatus
606   $aDeafness$xEtiology
606   $aDeafness$xTreatment
610   $aTGF-beta
610   $aNoise
610   $aHair cells
610   $aredox balance
610   $aspiral ganglion neurons
610   $aDrug delivery
610   $aARHL
610   $aAuditory Cortex
610   $aLipid homeostasis
610   $aInner ear
615  0$aPresbycusis.
615  0$aVestibular apparatus.
615  0$aDeafness$xEtiology.
615  0$aDeafness$xTreatment.
676   $a617.8
700   $aMarta Magarinos$4auth$01366880
702   $aMagariños$b Marta
702   $aMilo$b Marta
702   $aVarela-Nieto$b Isabel
801  2$bUkMaJRU
912   $a9910137088303321
996   $aAging, neurogenesis and neuroinflammation in hearing loss and protection$93389399
997   $aUNINA