LEADER 04330oam 2200589 450 001 9910137087203321 005 20230621135826.0 010 $a9782889196654$b(ebook) 035 $a(CKB)3710000000824760 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/60862 035 $a(EXLCZ)993710000000824760 100 $a20191103h20152015 fh 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aTherapeutic implications of circadian rhythms /$fedited by Guangrui Yang, Han Wang and Erquan Zhang 210 $cFrontiers Media SA$d2015 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d[2015] 210 4$dİ2015 215 $a1 online resource (96 pages) $cillustrations; digital file(s) 225 1 $aFrontiers Research Topics 300 $a"Published in: Frontiers in Pharmacology" -- front cover. 311 08$aPrint version: Therapeutic implications of circadian rhythms. [Lausanne, Switzerland] : Frontiers Media SA, 2015 2889196658 320 $aIncludes bibliographical references. 330 $aCircadian rhythms are biological processes displaying endogenous and entrainable oscillations of about 24 hours. They are driven by a group of genes called clock genes that have been widely observed in plants, animals and even in bacteria. In mammals, the core clock genes are rhythmically expressed in both the suprachiasmatic nucleus (SCN), the master clock residing in the hypothalamus, and almost all peripheral tissues where they control numerous target genes in a circadian manner, and thus affect many physiological and biochemical processes. Evidence suggests that disruption of the circadian rhythms (or desynchronization) is a significant risk factor for the development of metabolic diseases, cardiovascular diseases, cancer and sleep disorders. Evidence also suggests that the disruption suppresses immune function and increases vulnerability to infectious diseases. Restoring or strengthening the circadian rhythm may be therapeutic for these conditions. This becomes exceptionally important in modern societies because many people are suffering from frequent desynchronization due to shift working, exposure to artificial light, travel by transmeridian air flight, and involvement in social activities. Besides, the temporal variations in the incidence and severity of many diseases, such as the onset of cardiovascular events, chronic obstructive pulmonary disease (COPD), inflammatory diseases and mental disorders have also drawn increasing attention to the circadian clock. The circadian rhythms affect not only the health status, but also the drug efficiency. The effects (and side effects) of many drugs vary with biological timing. The tolerance of many medications displays circadian variation as well. The timing of medical treatment in coordination with the body clock may significantly increase the desired effects of drugs, and lower the dose and toxicity. In addition, circadian rhythms can also be modulated by some therapeutic drugs, for example, melatonin and modafinil, which are used to treat circadian rhythm sleep disorders. In this Research Topic, we assemble a series of critical review and research articles that focus on the therapeutic implications of circadian rhythms. 410 0$aFrontiers research topics. 606 $aCircadian rhythms$xHealth aspects 606 $aCircadian rhythms$xEffect of chemicals on 606 $aCircadian rhythms$xTherapeutic use 610 $aCardiovascular Diseases 610 $aCentral Nervous System 610 $aTherapeutic implications 610 $aCircadian Clocks 610 $aClinical relevance 610 $aCircadian Rhythm 610 $aMetabolism 610 $acircadian disruption 615 0$aCircadian rhythms$xHealth aspects. 615 0$aCircadian rhythms$xEffect of chemicals on 615 0$aCircadian rhythms$xTherapeutic use. 676 $a612.022 700 $aErquan Zhang$4auth$01365751 702 $aYang$b Guangrui 702 $aWang$b Han$cProfessor, 702 $aZhang$b Erquan 801 0$bUkMaJRU 906 $aBOOK 912 $a9910137087203321 996 $aTherapeutic implications of circadian rhythms$93387926 997 $aUNINA