LEADER 03065nam  2200433z- 450 
001 9910136817203321
005 20210211
035   $a(CKB)3710000000631044
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53954
035   $a(oapen)doab53954
035   $a(EXLCZ)993710000000631044
100   $a20202102d2016      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMorphogens in the wiring of the nervous system
210   $cFrontiers Media SA$d2016
215   $a1 online resource (238 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88919-781-6 
330   $aNeuronal function relies on the establishment of proper connections between neurons and their target cells during development. This basic statement involves several cellular processes, such as neuronal differentiation, the polarized outgrowth of axons and dendrites from differentiated neurons, and the pathfinding of axons towards target cells. The subsequent recognition of complementary synaptic partners finally triggers the formation, maturation, and maintenance of functional synapses. Morphogens are secreted signaling molecules commanding tissue patterning and cell identity during early embryonic development. Remarkably, growing evidence over the last years arising from different invertebrate and vertebrate model organisms has shown that, after cell fate has been established, morphogens also control the precise wiring and function in the developing and mature nervous system. Accordingly, dysfunctions of the signaling pathways activated by these molecules contribute to synaptic disassembly and altered function in diseases affecting the nervous system. We consider it timely to bring together cumulative evidence pointing to crucial roles for signaling activated by different morphogens in the establishment of precise contacts between neurons and their synaptic partners. Therefore, this research topic issue combines review and research articles aimed to cover the functional relevance of such morphogens on the different steps involved in synaptic assembly and function. Diverse model systems of physiological or pathological conditions have been included, as well as different cellular, biochemical and molecular approaches. Altogether, they contribute in different and complementary ways to build a holistic view of the roles that early development morphogens play during the assembly, maintenance and/or regeneration of functional synapses.
606   $aNeurosciences$2bicssc
610   $aBMP
610   $aMorphogens
610   $aNervous System
610   $aneurodegeneration
610   $aNeurogenesis
610   $aShh
610   $asynapse
610   $aWnt
615  7$aNeurosciences
700   $aNelson Osses$4auth$01309752
702   $aJuan Pablo Henriquez$4auth
906   $aBOOK
912   $a9910136817203321
996   $aMorphogens in the wiring of the nervous system$93029560
997   $aUNINA