LEADER 03150oam 2200565 450 001 9910136806803321 005 20230621135805.0 010 $z9782889197101$b(print) 035 $a(CKB)3710000000631079 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56451 035 $a(EXLCZ)993710000000631079 100 $a20191103h20152015 fy 0 101 0 $aeng 135 $aur||#|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aPodocyte pathology and nephropathy /$fedited by Barbara Lewko, Gavin Iain Welsh and Maciej Wojciech Jankowski 210 $cFrontiers Media SA$d2015 210 1$a[Lausanne, Switzerland] :$cFrontiers Media SA,$d[2015] 210 4$dİ2015 215 $a1 online resource (96 pages) $cillustrations (black and white, and colour); digital file(s) 225 1 $aFrontiers Research Topics 300 $a"Published in: Frontiers in Endocrinology" -- front cover. 311 08$aPrint version: 2889197107 320 $aIncludes bibliographical references. 330 $aThe understanding of the pathogenesis of diabetic nephropathy (DN) has advanced considerably in the last few years. Much has been learned about the natural history, the relative lack of significance of microalbuminuria in reflecting underlying pathological change, questionable effects of ACEs and ARBs on the progression of nephropathy, the emergence of new biomarkers such as Cystatin and the role of cytokines, inflammatory molecules and adhesion molecules. Podocytes, the cells with limited ability to replenish and to repair, play a pivotal role in glomerular filtration. In recent years these cells have become the focus for research on pathogenesis of DN as well as other nephropathies. A recent review from the NIH has identified new insights into the pathophysiology, the genetics and the role of the podocytes and some of the important new metabolic pathways such as mTOR or autophagy which may be targeting the podocyte. Knowledge is emerging about the role of podocyte as a part of immune system and about the role of growth factors and cytokines in regulation of podocyte functions. Presented in this e-book articles highlight recent advances in our understanding of the pathogenesis of kidney pathology and the role of podocytes in this process. 410 0$aFrontiers research topics. 606 $aDiabetic nephropathies 606 $aKidneys$xDiseases$xPathogenesis 606 $aPodocytes$xcytology 610 $aglomeruli 610 $aPodocytes 610 $afoot processes 610 $akidney disease 610 $aExosomes 610 $adiabetes 610 $aProteinuria 615 0$aDiabetic nephropathies. 615 0$aKidneys$xDiseases$xPathogenesis. 615 2$aPodocytes$xcytology. 676 $a616.462 700 $aMaciej Wojciech Jankowski$4auth$01367178 702 $aLewko$b Barbara 702 $aWelsh$b Gavin Iain 702 $aJankowski$b Maciej Wojciech 801 0$bUkMaJRU 912 $a9910136806803321 996 $aPodocyte pathology and nephropathy$93389897 997 $aUNINA