LEADER 03064nam  2200385z- 450 
001 9910136806503321
005 20240909184435.0
035   $a(CKB)3710000000631082
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/60915
035   $a(EXLCZ)993710000000631082
100   $a20202102d2016      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aThyroid hormone in brain and brain cells
210   $cFrontiers Media SA$d2016
215   $a1 electronic resource (106 p.)
225 1 $aFrontiers Research Topics
311   $a2-88919-702-6 
330   $aThyroid hormone signaling has been known for a long time to be required for proper neurodevelopment and the maintenance of cognitive functions in the adult brain. As thyroid hormone excess or deficiency is usually well handled by clinicians, research dedicated to the neural function of thyroid hormone, have not been a priority within the field. This is changing mainly for two reasons. First, new genetic diseases have been discovered, altering thyroid hormone signaling in brain (THRA, MCT8, SBP2), with neurodevelopmental consequences which are currently incurable. Second, there is a growing concern that exposition of the general population to environmental chemicals able to interfere with thyroid hormone signaling compromises children neurodevelopment or induces central disorders in adults. Finally thyroid hormone is acting directly on gene transcription, by binding nuclear receptors, and therefore is an interesting entry point to identify genetic programs controlling brain development and function. Reaching a broad understanding of the multiple processes involving thyroid hormone in brain is a tremendous task which will necessitate a multidisciplinary approach: animal genetics, molecular biology, brain imaging, developmental biology, genomics, etc... This topic will be the occasion to combine recent contributions in the field and to identify priorities for future investigations. Due to devastating consequences of congenital hypothyroidism, the neurodevelopmental consequences of altered thyroid hormone signaling have been extensively studied over the years. The discovery of new genetic diseases, the concern about the possible neurotoxicity of environmental thyroid hormone disruptors, recently renewed the interest for an important research field. This Ebook gathers reviews and original data from experts in various disciplines. It provides a broad view of ongoing research and outlines key issues for future investigation.
610   $athyroid hormone
610   $aneurodevelopment
610   $atransporter
610   $anuclear receptor
610   $abrain
610   $adeiodinase
700   $aBernal$b Juan$4auth$01769241
702   $aFlamant$b Frederic$4auth
702   $aKoibuchi$b Noriyuki$4auth
906   $aBOOK
912   $a9910136806503321
996   $aThyroid hormone in brain and brain cells$94237676
997   $aUNINA