LEADER 00998nam0-2200337---450- 001 990009297050403321 005 20110131112910.0 010 $a0863211739 035 $a000929705 035 $aFED01000929705 035 $a(Aleph)000929705FED01 035 $a000929705 100 $a20101213d1993----km-y0itay50------ba 101 1 $aita$aeng 102 $aGB 105 $a--------001yy 200 1 $aRuskin e la Toscana$fJeanne Clegg e Paul Tucker 210 $aSheffield$cRuskin Gallery$d1993 215 $a160 p.$cill.$d27 cm 300 $aIn testa al front: Edizione italiana in collaborazione con la Fondazione Ragghianti, Lucca 610 0 $aRuskin$aToscana$aEsposizione$a1993 676 $a760.074 700 1$aClegg,$bJean$0509659 701 1$aTucker,$bPaul$038979 801 0$aIT$bUNINA$gRICA$2UNIMARC 901 $aBK 912 $a990009297050403321 952 $a760.074 CLE 1$bBibl. 58922$fFLFBC 959 $aFLFBC 996 $aRuskin e la Toscana$9770606 997 $aUNINA LEADER 02979nam 2200457z- 450 001 9910136805303321 005 20210211 035 $a(CKB)3710000000631089 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55673 035 $a(oapen)doab55673 035 $a(EXLCZ)993710000000631089 100 $a20202102d2015 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aParkinson's Disease Cell Vulnerability and Disease Progression 210 $cFrontiers Media SA$d2015 215 $a1 online resource (194 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88919-676-3 330 $aParkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis of Parkinson's Disease remains unclear. Despite tremendous growth in recent years in our knowledge of the molecular basis of Parkinson's Disease and the molecular pathways of cell death important questions remain regarding why are substantia nigra cells especially vulnerable, which mechanisms underlie progressive cell loss or what do Lewy bodies or alpha-synuclein reveal about disease progression. Understanding the different vulnerability of the dopaminergic neurons from midbrain regions and the mechanisms whereby pathology becomes widespread are primary objectives of basic and clinical research in Parkinson's Disease. This e-Book discusses the etiopathogenesis of Parkinson's Disease, presenting a series of papers that provide up-to-date, state-of-the-art information on molecular and cellular mechanisms involved in the neurodegeneration process in the disease, the role of activation of functional anatomical organization of the basal ganglia and in particular habitual vs goal directed systems as a factor of neuronal vulnerability, the possibility that Parkinson's Disease coulb be a prion disease and how genetic factors linked to familial and sporadic forms of PD. We hope that this e-Book will stimulate the continuing efforts to understand the cell and physiological mechanisms underlying the origin of Parkinson's Disease. 606 $aNeurosciences$2bicssc 610 $aCell vulnerability 610 $aDopamine 610 $aDopaminergic Neurons 610 $ahabitual behavior 610 $aMitochondria 610 $aParkinson's Disease 610 $aStriatum 610 $aSubstantia Nigra 610 $asynuclein 615 7$aNeurosciences 700 $aJose A. Obeso$4auth$01328826 702 $aJavier Blesa$4auth 702 $aJose L. Lanciego$4auth 906 $aBOOK 912 $a9910136805303321 996 $aParkinson's Disease Cell Vulnerability and Disease Progression$93039002 997 $aUNINA